Risdiplam (CED0007231)

Record Information

Version

1.0

Creation Date

2026-04-14 20:13:30 UTC

Update Date

2026-08-21 22:05:03 UTC

Accession Number

CHEM132984

Identification

Common Name

Risdiplam

Class

Small Molecule

Description

Risdiplam is an organic compound with the formula C22H23N7O and an average molecular weight of 401.47 g/mol. Risdiplam belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is classified as an organoheterocyclic compound. This substance is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically those used as drugs for disorders of the musculo-skeletal system. The recorded exposure route for this compound is oral.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₂H₂₃N₇O

Average Molecular Mass

401.474 g/mol

Monoisotopic Mass

401.196 g/mol

CAS Registry Number

1825352-65-5

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CC1=CN2N=C(C=C(C)C2=N1)C1=CC(=O)N2C=C(C=CC2=N1)N1CCNC2(CC2)C1

InChI Identifier

InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3

InChI Key

ASKZRYGFUPSJPN-UHFFFAOYSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0000900000-9ebf438f9c47d7588b76	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0004900000-84c973c683bb281eb8b6	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0f7a-0009100000-6f212b375507afac6719	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0000900000-783728b82e711f3a95bd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0003900000-c0812c41f408819b6f4e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-059t-0219000000-ca106cec2fa3a76d5c14	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
247.0	Log mg/kg	[140:440]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
368	Drugs for disorders of the musculo-skeletal system	Healthcare, pharmaceuticals & veterinary products	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available

Pathways

1 pathway

Risdiplam Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Envelope glycoprotein gp160	P03377	Human immunodeficiency virus type 1 group M subtype B (isolateBRU/LAI) (HIV-1)	Predicted (SEA)	22.187
Click to view 3D structure	Activin receptor type-1	Q04771	Humans	Predicted (SEA)	3034.25
Click to view 3D structure	Glycogen synthase kinase-3 beta splice variant X1	A0A059UE90	Bos taurus	Predicted (SEA)	34.3315
Click to view 3D structure	Platelet-derived growth factor receptor beta	P09619	Humans	Predicted (SEA)	4069.02
Click to view 3D structure	Glycogen synthase kinase-3 beta	P49841	Humans	Predicted (SEA)	5442.05
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P19327	Rattus norvegicus	Predicted (SEA)	3262.43
Click to view 3D structure	Bone morphogenetic protein receptor type-1A	P36894	Humans	Predicted (SEA)	1808.9
Click to view 3D structure	Bone morphogenetic protein receptor type-1B	O00238	Humans	Predicted (SEA)	1687.23
Click to view 3D structure	Activin receptor type-1B	P36896	Humans	Predicted (SEA)	2042.14
Click to view 3D structure	Vascular endothelial growth factor receptor 2	P35968	Humans	Predicted (SEA)	6034.79
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P14842	Rattus norvegicus	Predicted (SEA)	3000.93
Click to view 3D structure	Aurora kinase B	Q96GD4	Humans	Predicted (SEA)	5675.44
Click to view 3D structure	Receptor-type tyrosine-protein kinase FLT3	P36888	Humans	Predicted (SEA)	5926.58
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	5335.55
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	5093.05
Click to view 3D structure	5-hydroxytryptamine receptor 7	P34969	Humans	Predicted (SEA)	4230.09
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	5473.35
Click to view 3D structure	Aurora kinase A	O14965	Humans	Predicted (SEA)	5770.88
Click to view 3D structure	TGF-beta receptor type-1	P36897	Humans	Predicted (SEA)	3195.71
Click to view 3D structure	Cyclin-dependent kinase 4	P11802	Humans	Predicted (SEA)	3197.66
Click to view 3D structure	Rho-associated protein kinase 1	Q13464	Humans	Predicted (SEA)	5731.8
Click to view 3D structure	Serine/threonine-protein kinase MRCK beta	Q9Y5S2	Humans	Predicted (SEA)	1830.78
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	4264.97
Click to view 3D structure	Cyclin-dependent kinase 2	P24941	Humans	Predicted (SEA)	5946.9
Click to view 3D structure	Cyclin-dependent kinase 9	P50750	Humans	Predicted (SEA)	4751.14