Belzutifan (CED0007940)

Record Information
Version1.0
Creation Date2026-04-14 20:18:37 UTC
Update Date2026-08-19 18:21:25 UTC
Accession NumberCHEM133112
Identification
Common NameBelzutifan
ClassSmall Molecule
Description
Belzutifan is an organic compound with the formula C17H12F3NO4S and an average molecular weight of 383.34 g/mol. Belzutifan belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. This compound is found in healthcare, pharmaceuticals, and veterinary products as an antineoplastic agent, with oral exposure being the recorded route. It acts as an inhibitor of the protein target Endothelial PAS domain-containing protein 1 (EPAS1). In terms of health effects, belzutifan is used as a treatment for renal cell carcinoma (PMC10132167).
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC17H12F3NO4S
Average Molecular Mass383.340 g/mol
Monoisotopic Mass383.044 g/mol
CAS Registry Number1672668-24-4
IUPAC NameNot Available
Traditional NameNot Available
SMILESCS(=O)(=O)C1=CC=C(OC2=CC(=CC(F)=C2)C#N)C2=C1[C@H](O)[C@H](F)[C@@H]2F
InChI IdentifierInChI=1S/C17H12F3NO4S/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10/h2-6,15-17,22H,1H3/t15-,16-,17+/m1/s1
InChI KeyLOMMPXLFBTZENJ-ZACQAIPSSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0009000000-8a73cd867799672a9c26Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0019-2916000000-bcd1f4a41b3ee7911159Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004r-9332000000-50d2412a4845bdb89462Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0009000000-903484d4c9c21c50c00cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0109000000-d310f7e756797ed25791Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0249000000-61392193544722612006Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
5340.0Log mg/kg[3000:9500]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
renal cell carcinomais_treatment_forNot AvailablePMC10132167
Exposure Sources
Source IDSourceSectorReference
358Antineoplastic agentsHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
1 pathway
Belzutifan Drug Metabolism Action Pathway
Belzutifan Drug Metabolism Action Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Endothelial PAS domain-containing protein 1 structureClick to view 3D structureEndothelial PAS domain-containing protein 1Q99814HumansPredicted (SEA)0.856341
Vascular endothelial growth factor A, long form structureClick to view 3D structureVascular endothelial growth factor A, long formP15692HumansPredicted (SEA)8.71911
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)3514.89
Click to view 3D structure4-hydroxyphenylpyruvate dioxygenaseO23920Daucus carotaPredicted (SEA)27.1694
Click to view 3D structureMetabotropic glutamate receptor 5P31424Rattus norvegicusPredicted (SEA)498.469
Solute carrier family 22 member 12 structureClick to view 3D structureSolute carrier family 22 member 12Q96S37HumansPredicted (SEA)52.7818
Click to view 3D structureC-X-C chemokine receptor type 2P35344Oryctolagus cuniculusPredicted (SEA)46.5538
Interleukin-18 structureClick to view 3D structureInterleukin-18Q14116HumansPredicted (SEA)113.738
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)6537.23
Click to view 3D structureProstaglandin-H2 D-isomeraseO02853Bos taurusPredicted (SEA)38.224
Bromodomain and PHD finger-containing protein 3 structureClick to view 3D structureBromodomain and PHD finger-containing protein 3Q9ULD4HumansPredicted (SEA)206.456
Transient receptor potential cation channel subfamily V member 4 structureClick to view 3D structureTransient receptor potential cation channel subfamily V member 4Q9HBA0HumansPredicted (SEA)552.029
Histamine H1 receptor structureClick to view 3D structureHistamine H1 receptorP35367HumansPredicted (SEA)4519.69
Sodium-dependent serotonin transporter structureClick to view 3D structureSodium-dependent serotonin transporterP31645HumansPredicted (SEA)4605.09
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansPredicted (SEA)5245.32
Bromodomain-containing protein 1 structureClick to view 3D structureBromodomain-containing protein 1O95696HumansPredicted (SEA)522.913
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)5805.29
Click to view 3D structureProtein phosphatase methylesterase 1Q8BVQ5Mus musculusPredicted (SEA)24.0554
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)7182.06
Sodium-dependent dopamine transporter structureClick to view 3D structureSodium-dependent dopamine transporterQ01959HumansPredicted (SEA)5189.2
Click to view 3D structureScytalone dehydrataseP56221Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae)Predicted (SEA)176.251
Peregrin structureClick to view 3D structurePeregrinP55201HumansPredicted (SEA)1030.72
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)7044.5
Alpha-2A adrenergic receptor structureClick to view 3D structureAlpha-2A adrenergic receptorP08913HumansPredicted (SEA)5101.15
D(1B) dopamine receptor structureClick to view 3D structureD(1B) dopamine receptorP21918HumansPredicted (SEA)3423.58
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available