Zuranolone (CED0011584)

Record Information

Version

1.0

Creation Date

2026-04-14 20:19:19 UTC

Update Date

2026-08-22 05:27:38 UTC

SynCED ID

CED0011584

Secondary Accession Numbers

CHEM133130

Identification

Common Name

Zuranolone

Class

Small Molecule

Description

Zuranolone is an organic compound with the chemical formula C25H35N3O2 and an average molecular weight of 409.57 g/mol. Zuranolone belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound is recorded as being found in or released from healthcare, pharmaceuticals, and veterinary products, specifically antidepressants, and is administered via the oral exposure route. Zuranolone acts on 16 recorded protein targets. It functions as a modulator or positive allosteric modulator of Gamma-aminobutyric acid receptor subunit pi (GABRP), Gamma-aminobutyric acid receptor subunit delta (GABRD), Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), and Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1), as well as 12 other proteins.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₅H₃₅N₃O₂

Average Molecular Mass

409.574 g/mol

Monoisotopic Mass

409.273 g/mol

CAS Registry Number

1632051-40-1

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@](C)(O)CC[C@]4([H])[C@@]3([H])CC[C@]12C)C(=O)CN1C=C(C=N1)C#N

InChI Identifier

InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1

InChI Key

HARRKNSQXBRBGZ-GVKWWOCJSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
738.0 Log mg/kg [420:1300]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
postpartum depression	Not Available	Not Available	An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth. (DO)	PMC13344627

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000377	Antidepressants?Antidepressants, a class of synthetic chemicals designed to alleviate symptoms of depression and anxiety, can enter the environment through various pathways, leading to contamination of water systems.	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Gamma-aminobutyric acid type B receptor subunit 1	Q9Z0U4	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.563 Applicability Domain 0.563 Statistical Significance 1.90e-04 Supporting Reference Compounds 1 E-value 1.47914
Click to view 3D structure	Sex hormone-binding globulin	P04278	Humans	Predicted (SEA)	Prediction Confidence Score 0.277 Applicability Domain 0.321 Statistical Significance 0.0033 Supporting Reference Compounds 33 E-value 25.5345
Click to view 3D structure	Corticosteroid-binding globulin	P08185	Humans	Predicted (SEA)	Prediction Confidence Score 0.277 Applicability Domain 0.321 Statistical Significance 0.0029 Supporting Reference Compounds 21 E-value 22.6541
Click to view 3D structure	Solute carrier family 22 member 3	O88446	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.269 Applicability Domain 0.321 Statistical Significance 0.0013 Supporting Reference Compounds 3 E-value 10.5096
Click to view 3D structure	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2	Q11205	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.255 Applicability Domain 0.255 Low confidence Statistical Significance 0.002 Supporting Reference Compounds 1 E-value 15.9591
Click to view 3D structure	3-oxo-5-alpha-steroid 4-dehydrogenase 2	P31213	Humans	Predicted (SEA)	Prediction Confidence Score 0.254 Applicability Domain 0.28 Low confidence Statistical Significance 0.0019 Supporting Reference Compounds 19 E-value 15.1806
Click to view 3D structure	3-oxo-5-alpha-steroid 4-dehydrogenase 1	P18405	Humans	Predicted (SEA)	Prediction Confidence Score 0.253 Applicability Domain 0.28 Low confidence Statistical Significance 0.0016 Supporting Reference Compounds 14 E-value 12.6894
Click to view 3D structure	Androgen receptor	P15207	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.252 Applicability Domain 0.28 Low confidence Statistical Significance 0.0095 Supporting Reference Compounds 73 E-value 73.9568
Click to view 3D structure	Mineralocorticoid receptor	P08235	Humans	Predicted (SEA)	Prediction Confidence Score 0.25 Applicability Domain 0.289 Low confidence Statistical Significance 0.01 Supporting Reference Compounds 74 E-value 78.0828
Click to view 3D structure	Cytochrome P450 2C19	P33261	Humans	Predicted (SEA)	Prediction Confidence Score 0.243 Applicability Domain 0.295 Low confidence Statistical Significance 0.4547 Supporting Reference Compounds 825 E-value 3540.04
Click to view 3D structure	Androgen receptor	P19091	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.24 Applicability Domain 0.28 Low confidence Statistical Significance 0.0045 Supporting Reference Compounds 19 E-value 35.4214
Click to view 3D structure	G-protein coupled bile acid receptor 1	Q8TDU6	Humans	Predicted (SEA)	Prediction Confidence Score 0.238 Applicability Domain 0.276 Low confidence Statistical Significance 0.0193 Supporting Reference Compounds 54 E-value 150.56
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.234 Applicability Domain 0.266 Low confidence Statistical Significance 0.6961 Supporting Reference Compounds 1245 E-value 5419.08
Click to view 3D structure	Progesterone receptor	Q690N0	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.231 Applicability Domain 0.266 Low confidence Statistical Significance 0.005 Supporting Reference Compounds 40 E-value 39.3139
Click to view 3D structure	3-hydroxy-3-methylglutaryl-coenzyme A reductase	P00347	Cricetulus griseus	Predicted (SEA)	Prediction Confidence Score 0.227 Applicability Domain 0.227 Low confidence Statistical Significance 0.0017 Supporting Reference Compounds 2 E-value 13.0008
Click to view 3D structure	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	P14060	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.239 Low confidence Statistical Significance 0.0016 Supporting Reference Compounds 3 E-value 12.6116
Click to view 3D structure	Androgen receptor	P10275	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.266 Low confidence Statistical Significance 0.0997 Supporting Reference Compounds 146 E-value 776.39
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.266 Low confidence Statistical Significance 0.0631 Supporting Reference Compounds 154 E-value 491.073
Click to view 3D structure	Aldo-keto reductase family 1 member B10	O60218	Humans	Predicted (SEA)	Prediction Confidence Score 0.225 Applicability Domain 0.276 Low confidence Statistical Significance 0.0358 Supporting Reference Compounds 49 E-value 278.778
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	Prediction Confidence Score 0.221 Applicability Domain 0.266 Low confidence Statistical Significance 0.1481 Supporting Reference Compounds 201 E-value 1152.71
Click to view 3D structure	Progesterone receptor	P06401	Humans	Predicted (SEA)	Prediction Confidence Score 0.219 Applicability Domain 0.266 Low confidence Statistical Significance 0.1106 Supporting Reference Compounds 119 E-value 860.701
Click to view 3D structure	Cytochrome P450 7B1	O75881	Humans	Predicted (SEA)	Prediction Confidence Score 0.217 Applicability Domain 0.217 Low confidence Statistical Significance 0.0013 Supporting Reference Compounds 1 E-value 10.5096
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase type 2	P80365	Humans	Predicted (SEA)	Prediction Confidence Score 0.216 Applicability Domain 0.238 Low confidence Statistical Significance 0.0068 Supporting Reference Compounds 32 E-value 53.3267
Click to view 3D structure	Solute carrier family 22 member 2	Q9R0W2	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.216 Applicability Domain 0.321 Statistical Significance 0.0015 Supporting Reference Compounds 14 E-value 11.366
Click to view 3D structure	Solute carrier organic anion transporter family member 1A1	P46720	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.216 Applicability Domain 0.289 Low confidence Statistical Significance 0.0033 Supporting Reference Compounds 10 E-value 25.5345