1,3,4,7,8,9,10,10-octachlorotricyclo[5.2.1.02,6]dec-8-ene (CED0145763)

Record Information
Version1.0
Creation Date2026-08-18 03:56:31 UTC
Update Date2026-08-18 03:56:31 UTC
Accession NumberCHEM150418
Identification
Common Name1,3,4,7,8,9,10,10-octachlorotricyclo[5.2.1.02,6]dec-8-ene
ClassSmall Molecule
Description
1,3,4,7,8,9,10,10-octachlorotricyclo[5.2.1.02,6]dec-8-ene belongs to the vinyl chlorides, a subclass of vinyl halides within the organic compounds. This compound has the formula C10H6Cl8 and an average molecular weight of 409.80 g/mol. It has been used industrially as a pesticide (PMC12249414, PMC3515905, PMC8494257, PMC9119311), an organochlorine pesticide (PMC8282629), an organochlorine insecticide (PMC11357934), and an insecticide (PMC8582917). The substance is found in or released from two recorded sources, specifically electrical and electronic equipment including amplifiers and video games. Exposure to this compound can occur via inhalation (PMC11675402). It is associated with several health effects, including obesity (PMC10008975) and low birth weight (PMC3551655). Additionally, it is linked to an increase in congenital hypothyroidism (PMC7009407) and an increase in cancer (PMC9280386), as well as general associations with cancer (PMC12249414, PMC3551655, PMC5132641).
Contaminant TypeNot Available
Chemical Structure
SynonymsNot Available
Chemical FormulaC10H6Cl8
Average Molecular Mass409.800 g/mol
Monoisotopic Mass405.798 g/mol
CAS Registry Number57-74-9
IUPAC NameNot Available
Traditional NameNot Available
SMILESNot Available
InChI IdentifierInChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2/t2?,3?,4?,5?,8-,9+/m0/s1
InChI KeyBIWJNBZANLAXMG-YQELWRJZSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
263.0Log mg/kg[150:470]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
cancerassociated_withincreasePMC9280386
cancerassociated_withNot AvailablePMC12249414 , PMC3551655 , PMC5132641
low birth weightassociated_withNot AvailablePMC3551655
obesityassociated_withNot AvailablePMC10008975
congenital hypothyroidismassociated_withincreasePMC7009407
Exposure Sources
Source IDSourceSectorReference
505AmplifiersElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
583Anchoring EquipmentMarine, shipping & aquacultureNot Available
597ChemosterilantsAgriculture & land managementNot Available
598Fertiliser DistributorsAgriculture & land managementNot Available
607Rodenticides(1)Agriculture & land managementNot Available
608RodenticidesAgriculture & land managementNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
histidine kinase structureClick to view 3D structurehistidine kinaseO32393Arthrospira platensisPredicted (SEA)0.233548
Click to view 3D structureGABA receptor subunitQ75NA5Musca domesticaPredicted (SEA)0.0778492
Gamma-aminobutyric acid receptor subunit beta-3 structureClick to view 3D structureGamma-aminobutyric acid receptor subunit beta-3P28472HumansPredicted (SEA)1.01204
Gamma-aminobutyric acid receptor subunit rho-1 structureClick to view 3D structureGamma-aminobutyric acid receptor subunit rho-1P24046HumansPredicted (SEA)98.3236
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)7767.09
Amine oxidase [flavin-containing] B structureClick to view 3D structureAmine oxidase [flavin-containing] BP27338HumansPredicted (SEA)7677.72
Click to view 3D structureSodium-dependent serotonin transporterP31652Rattus norvegicusPredicted (SEA)7676.48
Click to view 3D structureSodium-dependent dopamine transporterP23977Rattus norvegicusPredicted (SEA)7578.7
WD repeat-containing protein 91 structureClick to view 3D structureWD repeat-containing protein 91A4D1P6HumansPredicted (SEA)2591.44
Sodium-dependent serotonin transporter structureClick to view 3D structureSodium-dependent serotonin transporterP31645HumansPredicted (SEA)7767.33
Amine oxidase [flavin-containing] A structureClick to view 3D structureAmine oxidase [flavin-containing] AP21397HumansPredicted (SEA)7713.85
Sodium-dependent dopamine transporter structureClick to view 3D structureSodium-dependent dopamine transporterQ01959HumansPredicted (SEA)7772.31
Sodium-dependent noradrenaline transporter structureClick to view 3D structureSodium-dependent noradrenaline transporterP23975HumansPredicted (SEA)7770.91
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)7777.68
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)7778.93
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)7772.47
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)7778.69
Click to view 3D structureKynurenine 3-monooxygenaseP38169Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Predicted (SEA)1755.42
Lysine-specific histone demethylase 1A structureClick to view 3D structureLysine-specific histone demethylase 1AO60341HumansPredicted (SEA)7664.41
Click to view 3D structureSigma non-opioid intracellular receptor 1Q60492Cavia porcellusPredicted (SEA)7716.96
Histamine H1 receptor structureClick to view 3D structureHistamine H1 receptorP35367HumansPredicted (SEA)7770.83
Sigma non-opioid intracellular receptor 1 structureClick to view 3D structureSigma non-opioid intracellular receptor 1Q99720HumansPredicted (SEA)7776.83
Click to view 3D structureTransporterQ63380Rattus norvegicusPredicted (SEA)7318.45
Cytochrome P450 2B6 structureClick to view 3D structureCytochrome P450 2B6P20813HumansPredicted (SEA)7754.41
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)7780.02
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available