2-nitrosoguanidine (CED0041963)

Record Information
Version1.0
Creation Date2026-08-26 00:16:50 UTC
Update Date2026-08-26 00:16:50 UTC
SynCED IDCED0041963
Secondary Accession Numbers
  • CHEM272728
Identification
Common Name2-nitrosoguanidine
ClassSmall Molecule
Description
2-nitrosoguanidine is an organic nitrogen compound with the formula CH4N4O and an average molecular weight of 88.07 g/mol. 2-nitrosoguanidine belongs to the organic nitroso compounds, a subclass of organonitrogen compounds within the organic compounds. The substance is found in or released from nine recorded sources across various categories. Within food, food processing, and cookware, it is associated with brew kettles, fermentation processes for beer, the preparation of malt, the preparation of wort, and the preparation of wine or sparkling wine. In the category of household cleaning and consumer products, it is linked to soap detergents, perfumes within detergents and soaps, and cigar cigarettes. Additionally, the compound is recorded as being released from electrical and electronic equipment, specifically electric switches.
Contaminant TypeNot Available
Chemical Structure
SynonymsNot Available
Chemical FormulaCH4N4O
Average Molecular Mass88.070 g/mol
Monoisotopic Mass88.039 g/mol
CAS Registry Number674-81-7
IUPAC NameNot Available
Traditional NameNot Available
SMILESNot Available
InChI IdentifierInChI=1S/CH4N4O/c2-1(3)4-5-6/h(H4,2,3,4,6)
InChI KeyWTLKTXIHIHFSGU-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
  • mutagen (PMC13003683 )?A chemical substance that alters the genetic material of an organism, and increases the frequency of mutations above the naturally-occuring rate
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-000f-9000000000-6cb4d982eb3517132680Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
195.0 Log mg/kg [100:350]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementPubChem
CEDs000070Stormwater runoff?Stormwater runoff refers to the flow of rainwater or melted snow that does not soak into the ground and instead collects pollutants as it travels over impervious surfaces such as roads and parking lots.Automotive & urban infrastructurePubChem
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentPubChem
CEDs000517Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.Electrical & Electronic EquipmentPubChem
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentPubChem
CEDs000542Brew Kettles?Brew kettles are large vessels used in the brewing process for boiling ingredients such as malt, hops, and water.Food, food processing & cookwarePubChem
CEDs000544Fermentation Processes For Beer?Fermentation processes for beer involve the conversion of sugars into alcohol and carbon dioxide by yeast.Food, food processing & cookwarePubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000547Preparation Of Malt?Malt preparation involves the germination and drying of cereal grains, primarily barley, to produce malt for brewing and food products.Food, food processing & cookwarePubChem
CEDs000549Preparation Of Wine Or Sparkling Wine?The preparation of wine or sparkling wine involves various stages, including fermentation, aging, and bottling, which can introduce potential sources of synthetic chemical contamination.Food, food processing & cookwarePubChem
CEDs000550Preparation Of Wort?The preparation of wort involves the extraction of sugars from malted grains, a crucial step in the brewing process.Food, food processing & cookwarePubChem
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsPubChem
CEDs000579Manufacture Of Iron Or Steel?The manufacture of iron or steel involves various processes, including smelting, refining, and alloying, which can result in the release of synthetic chemicals and contaminants.Industrial manufacturing & chemical processingPubChem
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingPubChem
CEDs000600Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.Agriculture & land managementPubChem
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementPubChem
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementPubChem
CEDs000609Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.Personal care & cosmeticsPubChem
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsPubChem
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsPubChem
CEDs000630Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.Recreation & sports surfacesPubChem
CEDs000657Surface Finishing Of Leather?Surface finishing of leather often involves the use of various synthetic chemicals, including dyes, resins, and finishing agents.Textiles, leather & furnishingsPubChem
CEDs000678Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.Agriculture & land managementPubChem
CEDs000679Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.Agriculture & land managementPubChem
CEDs000684Cements?Cements are a composite material primarily used as a binding agent in construction applications, formed by the calcination of limestone and clay minerals at high temperatures.Building & ConstructionPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructurePubChem
CEDs000738Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.Industrial manufacturing & chemical processingPubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsPubChem
CEDs000742Leather Tanning?Leather tanning is a process that transforms raw animal hides into durable leather through the application of various chemicals, including chromium salts, aldehydes, and vegetable tannins.Textiles, leather & furnishingsPubChem
CEDs000743Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.Wastewater, sanitation & biosolidsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Solute carrier family 22 member 3 structureClick to view 3D structureSolute carrier family 22 member 3O75751HumansPredicted (SEA)
Prediction Confidence Score
0.156
Applicability Domain
0.172 Low confidence
Statistical Significance
0.0866
Supporting Reference Compounds
17
E-value
674.174
Urokinase-type plasminogen activator structureClick to view 3D structureUrokinase-type plasminogen activatorP00749HumansPredicted (SEA)
Prediction Confidence Score
0.156
Applicability Domain
0.172 Low confidence
Statistical Significance
0.8529
Supporting Reference Compounds
151
E-value
6639.99
Suppressor of tumorigenicity 14 protein structureClick to view 3D structureSuppressor of tumorigenicity 14 proteinQ9Y5Y6HumansPredicted (SEA)
Prediction Confidence Score
0.152
Applicability Domain
0.156 Low confidence
Statistical Significance
0.704
Supporting Reference Compounds
74
E-value
5480.51
Isopentenyl-diphosphate Delta-isomerase structureClick to view 3D structureIsopentenyl-diphosphate Delta-isomeraseQ46822Escherichia coli (strain K12)Predicted (SEA)
Prediction Confidence Score
0.152
Applicability Domain
0.152 Low confidence
Statistical Significance
0.0043
Supporting Reference Compounds
1
E-value
33.8644
Alpha-2A adrenergic receptor structureClick to view 3D structureAlpha-2A adrenergic receptorP08913HumansPredicted (SEA)
Prediction Confidence Score
0.151
Applicability Domain
0.171 Low confidence
Statistical Significance
0.9891
Supporting Reference Compounds
487
E-value
7700.3
Nitric oxide synthase, inducible structureClick to view 3D structureNitric oxide synthase, inducibleP35228HumansPredicted (SEA)
Prediction Confidence Score
0.15
Applicability Domain
0.278 Low confidence
Statistical Significance
0.6329
Supporting Reference Compounds
47
E-value
4926.92
Pleckstrin homology domain-containing family A member 1 structureClick to view 3D structurePleckstrin homology domain-containing family A member 1Q9HB21HumansPredicted (SEA)
Prediction Confidence Score
0.146
Applicability Domain
0.146 Low confidence
Statistical Significance
0.0018
Supporting Reference Compounds
1
E-value
13.7015
Polyamine oxidase 1 structureClick to view 3D structurePolyamine oxidase 1O64411Zea maysPredicted (SEA)
Prediction Confidence Score
0.145
Applicability Domain
0.185 Low confidence
Statistical Significance
0.0072
Supporting Reference Compounds
2
E-value
56.0514
Solute carrier family 22 member 1 structureClick to view 3D structureSolute carrier family 22 member 1O15245HumansPredicted (SEA)
Prediction Confidence Score
0.144
Applicability Domain
0.172 Low confidence
Statistical Significance
0.6753
Supporting Reference Compounds
30
E-value
5257.47
Diamine oxidase [copper-containing] structureClick to view 3D structureDiamine oxidase [copper-containing]P19801HumansPredicted (SEA)
Prediction Confidence Score
0.144
Applicability Domain
0.278 Low confidence
Statistical Significance
0.0479
Supporting Reference Compounds
11
E-value
373.053
Plasminogen structureClick to view 3D structurePlasminogenP00747HumansPredicted (SEA)
Prediction Confidence Score
0.143
Applicability Domain
0.158 Low confidence
Statistical Significance
0.9495
Supporting Reference Compounds
195
E-value
7391.71
Click to view 3D structureGag polyproteinP03373Avian erythroblastosis virus (strain ES4)Predicted (SEA)
Prediction Confidence Score
0.142
Applicability Domain
0.162 Low confidence
Statistical Significance
0.0214
Supporting Reference Compounds
4
E-value
166.987
Transmembrane protease serine 2 structureClick to view 3D structureTransmembrane protease serine 2O15393HumansPredicted (SEA)
Prediction Confidence Score
0.141
Applicability Domain
0.176 Low confidence
Statistical Significance
0.5761
Supporting Reference Compounds
23
E-value
4485.05
Click to view 3D structureDeoxyhypusine synthaseQ9GSW0Plasmodium falciparumPredicted (SEA)
Prediction Confidence Score
0.179
Applicability Domain
0.179 Low confidence
Statistical Significance
0.0058
Supporting Reference Compounds
1
E-value
44.9968
Click to view 3D structureSodium- and chloride-dependent creatine transporter 1P48029HumansPredicted (SEA)
Prediction Confidence Score
0.179
Applicability Domain
0.179 Low confidence
Statistical Significance
0.0017
Supporting Reference Compounds
1
E-value
12.923
Click to view 3D structureS-adenosylmethionine decarboxylase proenzymeP17708Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.168
Applicability Domain
0.2 Low confidence
Statistical Significance
0.0015
Supporting Reference Compounds
3
E-value
11.4438
Diamine acetyltransferase 1 structureClick to view 3D structureDiamine acetyltransferase 1P21673HumansPredicted (SEA)
Prediction Confidence Score
0.166
Applicability Domain
0.176 Low confidence
Statistical Significance
0.008
Supporting Reference Compounds
2
E-value
62.5129
Prothrombin structureClick to view 3D structureProthrombinP00734HumansPredicted (SEA)
Prediction Confidence Score
0.164
Applicability Domain
0.208 Low confidence
Statistical Significance
0.9192
Supporting Reference Compounds
331
E-value
7156.29
Acrosin structureClick to view 3D structureAcrosinP08001Sus scrofaPredicted (SEA)
Prediction Confidence Score
0.163
Applicability Domain
0.208 Low confidence
Statistical Significance
0.0394
Supporting Reference Compounds
8
E-value
306.959
Click to view 3D structureDeoxyhypusine synthaseQ6AY53Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.162
Applicability Domain
0.185 Low confidence
Statistical Significance
0.0039
Supporting Reference Compounds
3
E-value
30.0498
Coagulation factor X structureClick to view 3D structureCoagulation factor XP00742HumansPredicted (SEA)
Prediction Confidence Score
0.159
Applicability Domain
0.208 Low confidence
Statistical Significance
0.9294
Supporting Reference Compounds
284
E-value
7235.31
Click to view 3D structureDiamine oxidase [copper-containing]P36633Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.159
Applicability Domain
0.2 Low confidence
Statistical Significance
0.0031
Supporting Reference Compounds
3
E-value
24.5225
Serine protease 1 structureClick to view 3D structureSerine protease 1P00760Bos taurusPredicted (SEA)
Prediction Confidence Score
0.158
Applicability Domain
0.208 Low confidence
Statistical Significance
0.607
Supporting Reference Compounds
74
E-value
4725.45
Protein phosphatase 1 regulatory subunit 15A structureClick to view 3D structureProtein phosphatase 1 regulatory subunit 15AO75807HumansPredicted (SEA)
Prediction Confidence Score
0.158
Applicability Domain
0.158 Low confidence
Statistical Significance
0.0142
Supporting Reference Compounds
1
E-value
110.546
Protein phosphatase 1 regulatory subunit 15B structureClick to view 3D structureProtein phosphatase 1 regulatory subunit 15BQ5SWA1HumansPredicted (SEA)
Prediction Confidence Score
0.158
Applicability Domain
0.158 Low confidence
Statistical Significance
0.0142
Supporting Reference Compounds
1
E-value
110.546
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available