Furosemide (Frusemide) (CED0001485)

Furosemide (Frusemide) belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. This benzenoid compound has the formula C12H11ClN2O5S and an average molecular weight of 330.74 g/mol. It functions as a biological diuretic (PMC10884053, PMC7112026). Its recorded protein targets include the G-protein coupled receptor 35 (GPR35), Carbonic anhydrase 2 (CA2), and the Solute carrier family 12 member 1 (SLC12A1), for which it acts as an agonist/inhibitor. Furosemide is used as a treatment for high blood pressure (PMC10698095), hypertension (PMC13344627), hypercalcemia (PMC1492602), and congestive heart failure (PMC10193417, PMC1492602). Exposure routes for the compound include oral, intravenous, intravascular, subcutaneous, intramuscular, and topical administration. It has been found in or released from 66 recorded sources across multiple sectors. These include healthcare, pharmaceuticals and veterinary products, such as gynecologicals and diuretics; food, food processing and cookware, including food preservation and the preparation of malt, vinegar, beer fermentation processes, and wine or sparkling wine; household items such as key rings, coins, and credit card holders; building and construction materials including roofs, ladders, floors, fencing, and ceilings; household cleaning and consumer products such as bleaching agents, ash trays, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices; and electrical and electronic equipment, including amplifiers, antennas, coils, adjustable resistors, auxiliary devices, and 27 additional sources.