Methylprednisolone (CED0001025)

Record Information
Version1.0
Creation Date2016-05-22 03:43:30 UTC
Update Date2026-05-14 16:54:09 UTC
SynCED IDCED0001025
Secondary Accession Numbers
  • CHEM016781
Identification
Common NameMethylprednisolone
ClassSmall Molecule
Description
Methylprednisolone (C22H30O5) is an organic compound with an average molecular weight of 374.47 g/mol. Methylprednisolone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. Biologically, it functions as a glucocorticoid (PMC12227235 ) and acts as an agonist of the Glucocorticoid receptor (NR3C1) and Annexin A1 (ANXA1). The compound is used in the treatment of COVID-19 (PMC8000639 ), diarrhea (PMC8128374 ), and the symptoms of weakness, dysarthria, and salivation (PMC9907188 ). Additionally, it has therapeutic effects on necrosis and liver inflammation (PMC8464467 ), as well as general inflammation (PMC11459094 ). Methylprednisolone is found in 25 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as corticosteroids, anti-acne preparations, ophthalmological and otological preparations, and combinations of corticosteroids with antibiotics or antiinflammatory agents and antiinfectives. It is also associated with food, food processing, and cookware, specifically the preparation of wine or sparkling wine, food preservation, processing meats, and fermentation processes for beer. Other recorded sources include indoor air and various household cleaning and consumer products, such as soap detergents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. It is also found in electrical and electronic equipment, including antennas, electrodes, discharge lamps, conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. Recorded exposure routes include oral, topical, subcutaneous, intramuscular, intravenous, intravascular, intra-arterial, intra-articular, intrasynovial, periarticular, perineural, intralesional, intrabursal, intrabronchial, intrathecal, intrameningeal, intracaudal, infiltration, parenteral, epidural, soft tissue, and inhalation.
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dioneChEBI
1-Dehydro-6alpha-methylhydrocortisoneChEBI
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dioneChEBI
Delta(1)-6alpha-MethylhydrocortisoneChEBI
MedrateChEBI
MedrolChEBI
MedroneChEBI
MethylprednisolonChEBI
MethylprednisolonumChEBI
MetilprednisolonaChEBI
SolometChEBI
UrbasonChEBI
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dioneGenerator
(6Α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dioneGenerator
1-Dehydro-6a-methylhydrocortisoneGenerator
1-Dehydro-6α-methylhydrocortisoneGenerator
6a-Methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dioneGenerator
6Α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dioneGenerator
delta(1)-6a-MethylhydrocortisoneGenerator
Δ(1)-6α-methylhydrocortisoneGenerator
Medric acidGenerator
Δ(1)-6a-methylhydrocortisoneHMDB
6alpha-MethylprednisoloneHMDB
MethyleneprednisoloneHMDB
MetilprednisoloneHMDB
6 MethylprednisoloneHMDB
6-MethylprednisoloneHMDB
MetipredHMDB
MethylprednisoloneChEBI
6a-MethylprednisoloneGenerator
6Α-methylprednisoloneGenerator
Chemical FormulaC22H30O5
Average Molecular Mass374.471 g/mol
Monoisotopic Mass374.209 g/mol
CAS Registry Number83-43-2
IUPAC Name(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
Traditional Namemethylprednisolone
SMILES[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
InChI IdentifierInChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChI KeyVHRSUDSXCMQTMA-PJHHCJLFSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • 20-oxosteroid
  • Pregnane-skeleton
  • 3-oxo-delta-1,4-steroid
  • 3-oxosteroid
  • Oxosteroid
  • 11-beta-hydroxysteroid
  • 11-hydroxysteroid
  • 17-hydroxysteroid
  • Delta-1,4-steroid
  • Cyclic alcohol
  • Tertiary alcohol
  • Alpha-hydroxy ketone
  • Ketone
  • Secondary alcohol
  • Cyclic ketone
  • Primary alcohol
  • Alcohol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.11 g/LALOGPS
logP2.06ALOGPS
logP1.56ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)12.58ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity103.04 m³·mol⁻¹ChemAxon
Polarizability40.84 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0a5c-4897000000-e8a5119b3469a050dd85Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-004i-1325090000-5d0a8d05c100c594a651Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0bti-0896000000-86854a3fa2cb3c3bde0bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0796000000-b0070da713077c3f7975Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-3950000000-b938f656c358e1e42bb5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0019000000-3a4955cf7cc34e1e8d0fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0k9i-0696000000-003c4527b983cf71aefdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-e5097669b38e84057a0fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-ef914702163187cc80afNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-54b01b6c04c68be3f1b3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-3fe2869617af3697e2edNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-8ad4f169606968256614Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0f79-0895000000-29d1cbf49bb2b32c5a98Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0940000000-baa402ac94c228229ea2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0910000000-5cf9fb219d798a9316f4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0910000000-a2d2af7f573229dc3147Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-2900000000-a01d5bfe926dc48e6e4cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0019000000-11519ee9583104c00505Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0gw0-0974000000-af5d4ebce055ce6efb23Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-22e2342fcec2bf1cd833Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0920000000-63759535c53af1efb13fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0c09-1900000000-a48c07db31cf27cf0381Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05tp-2900000000-b802f5e17b69cd6c707fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-0e0cc8bfc7721357c5cfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0bti-0896000000-86854a3fa2cb3c3bde0bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0796000000-b0070da713077c3f7975Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-3950000000-b938f656c358e1e42bb5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-6e422dc07ae506032de2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-09e0458538015ae2791bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-5d0333810dd91d2da111Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0bti-1930000000-58934d5fa4756fcae186Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-2910000000-d48f8b47dd04090330a2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0009000000-3e7c1096a3dc1b191179Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-a8f6e347340e64b35370Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-047089858b1f6056ef5cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0k9i-0696000000-ff9ef083fec8324bcf77Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-2910000000-5e9d6b53767c0f0e1a46Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-2910000000-8bdfcae20d866dfa3d03Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-d216577532b3ebf3514cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0ly9-0696000000-24f79cfbbf915de6b831Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-ed0202b2fc763b57a2bbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052r-0696000000-9f9f792dbd9c923f1657Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-7ebde6f0be05f3187ab4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0009000000-75c3a555a9d5bb02eb13Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0k9i-0696000000-e183af1477576abb6fe0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0009000000-939fa00b6689c67a336cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0940000000-baa402ac94c228229ea2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0950000000-9e2ce63f43e8479cca67Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-f412b8f97317d4af041fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-c088181e8119ff992861Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0f79-0895000000-29d1cbf49bb2b32c5a98Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0910000000-a2d2af7f573229dc3147Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-d7c858859d8b41ec0d23Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-676549ff9a9eeecbb214Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0910000000-5cf9fb219d798a9316f4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-e16d6abd80ecf359456aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0019000000-11519ee9583104c00505Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0gw0-0974000000-af5d4ebce055ce6efb23Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-8ad4f169606968256614Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0980000000-6c0f3e016150805707e9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0009000000-0e0cc8bfc7721357c5cfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-9201541d70a8c069d4fcNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-6cc7fa3019080d46959cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0c09-1900000000-a48c07db31cf27cf0381Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0k9i-0696000000-371ac3d632243883b947Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-22e2342fcec2bf1cd833Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0009000000-6b858ab44f87eaa31459Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0920000000-63759535c53af1efb13fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0890000000-737ebf112e915dd0cbd5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-35d148f865878cd7ea30Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0ly9-0696000000-0e89aebde9b13325a274Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0bti-1930000000-0f7d1d88329a7d1f9c90Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0019000000-af7c1a42690984644d07Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0960000000-a5ce0b91637bc6ff4fc7Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06y9-0940000000-aba3867bf5ce8b1f3701Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0239000000-85eda381dc84f3c0cca3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a6r-0009000000-f8f6ab30d16fdc075eedNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p9-0950000000-cae6c9a4487520c602c9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0gw0-0972000000-06420dbc952f62b5fa6eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a6r-0019000000-0cb8333360b09d8df53eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4r-0249000000-56520a54507e1870e5a6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-01c1-1793000000-d51395bd0972f5b8c5efNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009000000-d97cc17b3e3a9c57c8ffNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-2029000000-2b2ea4b2dc572fa1808bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-8096000000-fe46a5f1c12f4f84faf3Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0009000000-608fefd099c198eb6908Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0956000000-30d93e6ef18457408101Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00b9-4590000000-83b80fd01b652a7eeb9eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0006-0009000000-1d80aa5cfc294407ff77Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00kf-0019000000-2471d578316ef9c35758Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00kb-1079000000-541498bbd633a6560fcdNot AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
842.0 Log mg/kg [470:1500]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
arthritisNot AvailableNot AvailableA disorder characterized by inflammation involving a joint. (NCI CTCAE)PMC5527234
inflammationHas Therapeutic Effect OnNot AvailableNot AvailablePMC11459094
inflammationNot AvailableNot AvailableNot AvailablePMC11474175
asthmaNot AvailableNot AvailableA bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has symptom recurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (DO)PMC11459094 , PMC3075899
diarrheaNot AvailableNot AvailableA disorder characterized by an increase in frequency and/or loose or watery bowel movements. (NCI CTCAE)PMC8128374
necrosisHas Therapeutic Effect OnNot AvailableA disorder characterized as a form of cell injury which results in the premature death of cells in living tissue by autolysis.PMC8464467
liver inflammationHas Therapeutic Effect OnNot AvailableNot AvailablePMC8464467
hepatitisHas Therapeutic Effect OnNot AvailableA disorder characterized by an inflammation of the liver. (NCI CTCAE)PMC8464467
COVID-19Not AvailableNot AvailableNot AvailablePMC8000639 , PMC9380879
edemaHas Therapeutic Effect OnNot AvailableA disorder characterized by swelling due to an excessive accumulation of fluid (NCI CTCAE)PMC12466678
liver diseaseAssociated With?Not AvailableA disorder characterized by any variety of factors leading to damage to the liver.PMC9701571
Chronic Obstructive Pulmonary DiseaseNot AvailableNot AvailableA disorder characterized by long-term breathing problems and poor airflow, commonly attributed to smoking.PMC3075899
dyspneaNot AvailableNot AvailableNot AvailablePMC10831387
weaknessNot AvailableNot AvailableNot AvailablePMC9907188
salivationNot AvailableNot AvailableNot AvailablePMC9907188
dysarthriaNot AvailableNot AvailableA disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech. (NCI CTCAE)PMC9907188
colitisNot AvailableNot AvailableA disorder characterized by inflammation of the colon. (NCI CTCAE)PMC5527234
meningitisAssociated With?Not AvailableA disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. (NCI CTCAE)PMC12300887
fungal meningitisAssociated With?Not AvailableNot AvailablePMC4137817
MortalityAssociated With?increaseNot AvailablePMC3943200
MortalityHas Therapeutic Effect OnNot AvailableNot AvailablePMC12846521
FibrosisHas Therapeutic Effect OnNot AvailableNot AvailablePMC8464467
Reperfusion InjuryNot AvailableNot AvailableNot AvailablePMC5760809
ErythemaHas Therapeutic Effect OnNot AvailableNot AvailablePMC12568756
dry eye syndromeNot AvailableNot AvailableNot AvailablePMC6766080
spinal cord injuryNot AvailableNot AvailableNot AvailablePMC7536552 , PMC12466678
engraftment syndromeNot AvailableNot AvailableNot AvailablePMC9387014
Interstitial pneumonitisNot AvailableNot AvailableNot AvailablePMC11225133
Intracranial PressureNot AvailableNot AvailableNot AvailablePMC11474175
Exposure Sources
Source IDSourceSectorReference
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementPubChem
CEDs000019Indoor air?Indoor air can be a significant reservoir for synthetic chemical contaminants, which often originate from various sources within enclosed environments.Air, dust & atmospheric transportNot Available
CEDs000233Brushes?Brushes used in personal care and cosmetics can be a source of synthetic chemical contamination due to the materials and coatings used in their manufacturing.Personal care & cosmeticsPubChem
CEDs000309Corticosteroids?Corticosteroids are synthetic drugs that mimic the effects of hormones produced by the adrenal glands and are widely used for their anti-inflammatory and immunosuppressive properties.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000311Corticosteroids, combinations with antibiotics?Corticosteroids are a class of synthetic chemicals that mimic the effects of hormones produced by the adrenal glands.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000314Anti-acne preparations?Anti-acne preparations often contain synthetic chemicals such as benzoyl peroxide, salicylic acid, and various retinoids.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000397Antiinflammatory agents and antiinfectives in combination?Anti-inflammatory agents and anti-infectives are classes of synthetic chemicals widely used in the treatment of various medical conditions.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000407Ophthalmological and otological preparations?Ophthalmological and otological preparations are formulations designed for the treatment of eye and ear conditions, respectively.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000506Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.Electrical & Electronic EquipmentPubChem
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentPubChem
CEDs000514Discharge Lamps?Discharge lamps, including fluorescent and high-intensity discharge (HID) lamps, are commonly used for lighting applications due to their energy efficiency and brightness.Electrical & Electronic EquipmentPubChem
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentPubChem
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentPubChem
CEDs000520Emergency Protective Devices?Emergency protective devices, such as circuit breakers and surge protectors, are essential components in electrical systems designed to prevent damage from overcurrent and surges.Electrical & Electronic EquipmentPubChem
CEDs000524Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.Electrical & Electronic EquipmentPubChem
CEDs000537Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.Electrical & Electronic EquipmentPubChem
CEDs000544Fermentation Processes For Beer?Fermentation processes for beer involve the conversion of sugars into alcohol and carbon dioxide by yeast.Food, food processing & cookwarePubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000549Preparation Of Wine Or Sparkling Wine?The preparation of wine or sparkling wine involves various stages, including fermentation, aging, and bottling, which can introduce potential sources of synthetic chemical contamination.Food, food processing & cookwarePubChem
CEDs000552Processing Meats?Processing meats can lead to synthetic chemical contamination primarily through the use of additives and preservatives.Food, food processing & cookwarePubChem
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsPubChem
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsPubChem
CEDs000560Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsPubChem
CEDs000566Tobacco Pipes?Tobacco pipes, often made from materials such as plastic, wood, or metal, can serve as sources of synthetic chemical contamination due to the residues left by tobacco products.Household cleaning & consumer productsPubChem
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsPubChem
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingPubChem
CEDs000596Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.Agriculture & land managementPubChem
CEDs000602Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.Agriculture & land managementPubChem
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementPubChem
CEDs000605Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.Agriculture & land managementPubChem
CEDs000607Rodenticides(1)?Rodenticides are synthetic chemicals specifically formulated to control rodent populations, serving as a crucial tool in managing pests that can damage crops and spread diseases.Agriculture & land managementPubChem
CEDs000608Rodenticides?Rodenticides are chemical substances specifically designed to control rodent populations by causing death through various mechanisms, including anticoagulation or neurotoxicity.Agriculture & land managementPubChem
CEDs000609Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.Personal care & cosmeticsPubChem
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsPubChem
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000613Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.Personal care & cosmeticsPubChem
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsPubChem
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsPubChem
CEDs000616Face Mask Cosmetics?Face mask cosmetics often contain a variety of synthetic chemicals, including preservatives, emulsifiers, and fragrances, which can contribute to chemical contamination.Personal care & cosmeticsPubChem
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsPubChem
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsPubChem
CEDs000642Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.Textiles, leather & furnishingsPubChem
CEDs000650Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.Textiles, leather & furnishingsPubChem
CEDs000651Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.Textiles, leather & furnishingsPubChem
CEDs000655Slide Fasteners?Slide fasteners, commonly known as zippers, are mechanical devices used to join two edges of fabric or other materials.Textiles, leather & furnishingsPubChem
CEDs000667Gaseous Fire Fighting?Gaseous fire fighting systems utilize synthetic chemicals, such as halocarbons and inert gases, to suppress fires through chemical and physical processes.Fire suppression systems & agentsPubChem
CEDs000671Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.Aviation & AerospacePubChem
CEDs000674Bridle Bits?Bridle bits, commonly used in equestrian activities, can be a source of synthetic chemical contamination primarily through the materials used in their manufacturing.Agriculture & land managementPubChem
CEDs000677Horse Reins?Horse reins, often made from synthetic materials such as nylon or polyester, can be a source of chemical contamination due to their production and degradation processes.Agriculture & land managementPubChem
CEDs000678Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.Agriculture & land managementPubChem
CEDs000684Cements?Cements are a composite material primarily used as a binding agent in construction applications, formed by the calcination of limestone and clay minerals at high temperatures.Building & ConstructionPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000688Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.Building & ConstructionPubChem
CEDs000692Silica Free Oxide Glass?Silica Free Oxide Glass is a type of glass that is produced using alternative materials to traditional silica-based formulations.Building & ConstructionPubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000698Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.Mining & metal processingPubChem
CEDs000727Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.Paper, pulp & fiber productsPubChem
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructurePubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsPubChem
CEDs000741Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.Paper, pulp & fiber productsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
2 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Glucocorticoid receptor structureClick to view 3D structureGlucocorticoid receptorP04150HumansPredicted (SEA)
Prediction Confidence Score
0.628
Applicability Domain
1.0
Statistical Significance
1.70e-04
Supporting Reference Compounds
154
E-value
1.32344
Mineralocorticoid receptor structureClick to view 3D structureMineralocorticoid receptorP08235HumansPredicted (SEA)
Prediction Confidence Score
0.474
Applicability Domain
0.705
Statistical Significance
4.00e-04
Supporting Reference Compounds
74
E-value
3.11397
Glucocorticoid receptor structureClick to view 3D structureGlucocorticoid receptorP06536Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.469
Applicability Domain
0.705
Statistical Significance
2.00e-04
Supporting Reference Compounds
26
E-value
1.55698
Click to view 3D structureNuclear receptor subfamily 1 group I member 2Q9R1A7Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.464
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
12
E-value
0.0778492
Corticosteroid-binding globulin structureClick to view 3D structureCorticosteroid-binding globulinP08185HumansPredicted (SEA)
Prediction Confidence Score
0.45
Applicability Domain
0.705
Statistical Significance
4.40e-04
Supporting Reference Compounds
21
E-value
3.42537
Progesterone receptor structureClick to view 3D structureProgesterone receptorP06401HumansPredicted (SEA)
Prediction Confidence Score
0.43
Applicability Domain
0.705
Statistical Significance
0.0014
Supporting Reference Compounds
119
E-value
10.9767
Glucocorticoid receptor structureClick to view 3D structureGlucocorticoid receptorP06537Mus musculusPredicted (SEA)
Prediction Confidence Score
0.409
Applicability Domain
0.705
Statistical Significance
1.20e-04
Supporting Reference Compounds
10
E-value
0.934191
Click to view 3D structureProgesterone receptorQ690N0Bos taurusPredicted (SEA)
Prediction Confidence Score
0.385
Applicability Domain
0.465
Statistical Significance
7.40e-04
Supporting Reference Compounds
40
E-value
5.76084
Estrogen receptor structureClick to view 3D structureEstrogen receptorP03372HumansPredicted (SEA)
Prediction Confidence Score
0.38
Applicability Domain
0.705
Statistical Significance
0.0037
Supporting Reference Compounds
201
E-value
28.9599
Sex hormone-binding globulin structureClick to view 3D structureSex hormone-binding globulinP04278HumansPredicted (SEA)
Prediction Confidence Score
0.374
Applicability Domain
0.537
Statistical Significance
0.0013
Supporting Reference Compounds
33
E-value
10.4318
Androgen receptor structureClick to view 3D structureAndrogen receptorP10275HumansPredicted (SEA)
Prediction Confidence Score
0.373
Applicability Domain
0.705
Statistical Significance
0.0034
Supporting Reference Compounds
146
E-value
26.1573
Estrogen receptor beta structureClick to view 3D structureEstrogen receptor betaQ92731HumansPredicted (SEA)
Prediction Confidence Score
0.365
Applicability Domain
0.705
Statistical Significance
0.003
Supporting Reference Compounds
174
E-value
23.2769
Androgen receptor structureClick to view 3D structureAndrogen receptorP15207Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.36
Applicability Domain
0.465
Statistical Significance
0.0022
Supporting Reference Compounds
73
E-value
17.049
G-protein coupled bile acid receptor 1 structureClick to view 3D structureG-protein coupled bile acid receptor 1Q8TDU6HumansPredicted (SEA)
Prediction Confidence Score
0.316
Applicability Domain
0.705
Statistical Significance
0.0048
Supporting Reference Compounds
54
E-value
37.679
Click to view 3D structureTyrosine aminotransferaseP04694Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.308
Applicability Domain
0.311
Statistical Significance
2.00e-04
Supporting Reference Compounds
2
E-value
1.55698
Interstitial collagenase structureClick to view 3D structureInterstitial collagenaseP03956HumansPredicted (SEA)
Prediction Confidence Score
0.281
Applicability Domain
0.318
Statistical Significance
0.0468
Supporting Reference Compounds
258
E-value
364.724
Disintegrin and metalloproteinase domain-containing protein 17 structureClick to view 3D structureDisintegrin and metalloproteinase domain-containing protein 17P78536HumansPredicted (SEA)
Prediction Confidence Score
0.27
Applicability Domain
0.705
Statistical Significance
0.0328
Supporting Reference Compounds
166
E-value
255.501
Pyruvate carboxylase, mitochondrial structureClick to view 3D structurePyruvate carboxylase, mitochondrialP11498HumansPredicted (SEA)
Prediction Confidence Score
0.262
Applicability Domain
0.372
Statistical Significance
1.50e-04
Supporting Reference Compounds
2
E-value
1.16774
Fatty acid-binding protein, liver structureClick to view 3D structureFatty acid-binding protein, liverP02692Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.251
Applicability Domain
0.705
Statistical Significance
0.001
Supporting Reference Compounds
13
E-value
8.09632
Tumor necrosis factor structureClick to view 3D structureTumor necrosis factorP01375HumansPredicted (SEA)
Prediction Confidence Score
0.249
Applicability Domain
0.705
Statistical Significance
0.0258
Supporting Reference Compounds
81
E-value
201.24
Bile salt export pump structureClick to view 3D structureBile salt export pumpO95342HumansPredicted (SEA)
Prediction Confidence Score
0.244
Applicability Domain
0.278 Low confidence
Statistical Significance
0.0352
Supporting Reference Compounds
104
E-value
273.951
Click to view 3D structureSolute carrier family 22 member 3O88446Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.243
Applicability Domain
0.308
Statistical Significance
0.0019
Supporting Reference Compounds
3
E-value
14.7135
Androgen receptor structureClick to view 3D structureAndrogen receptorP19091Mus musculusPredicted (SEA)
Prediction Confidence Score
0.238
Applicability Domain
0.325
Statistical Significance
0.0048
Supporting Reference Compounds
19
E-value
37.2898
Protein kinase C eta type structureClick to view 3D structureProtein kinase C eta typeP24723HumansPredicted (SEA)
Prediction Confidence Score
0.237
Applicability Domain
0.376
Statistical Significance
0.1061
Supporting Reference Compounds
145
E-value
826.214
Interleukin-6 structureClick to view 3D structureInterleukin-6P05231HumansPredicted (SEA)
Prediction Confidence Score
0.233
Applicability Domain
0.705
Statistical Significance
1.80e-04
Supporting Reference Compounds
9
E-value
1.40129
Concentrations
StatusValueUnitSample LocationReference
Not Detected
External Links
DrugBank IDDB00959
HMDB IDHMDB0015094
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkMethylprednisolone
Chemspider ID6485
ChEBI ID6888
PubChem Compound ID6741
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available