Bezafibrate (CED0004197)

Record Information
Version1.0
Creation Date2016-05-22 04:13:50 UTC
Update Date2026-08-20 02:48:34 UTC
Accession NumberCHEM017302
Identification
Common NameBezafibrate
ClassSmall Molecule
Description
Bezafibrate is an organic compound with the formula C19H20ClNO4 and an average molecular weight of 361.82 g/mol. Bezafibrate belongs to the phenoxyacetic acid derivatives, a subclass of benzene and substituted derivatives within the organic compounds. Biologically, the compound acts as an endocrine disruptor (PMC10000190). It interacts with seven recorded protein targets, functioning as an agonist or partial agonist of Peroxisome proliferator-activated receptor alpha (PPARA), Peroxisome proliferator-activated receptor delta (PPARD), Peroxisome proliferator-activated receptor gamma (PPARG), and Nuclear receptor subfamily 1 group I member 2 (NR1I2), in addition to three other proteins. The compound is found in or released from six recorded sources. These include healthcare, pharmaceuticals, and veterinary products as lipid modifying agents; drinking water and water supply; and food, food processing, and cookware specifically in the preparation of vinegar. It is also associated with household cleaning and consumer products such as non-electric simulated smoking devices, as well as electrical and electronic equipment including electric hearing aids and electrically stimulated smoking devices. The recorded exposure route for bezafibrate is oral.
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acidChEBI
BefizalChEBI
BezafibratoChEBI
BezafibratumChEBI
BezalipChEBI
Bezatol SRChEBI
CedurChEBI
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionateGenerator
Bezafibric acidGenerator
BezafibratHMDB
BefibratHMDB
Beza purenHMDB
Bezafibrat PBHMDB
Bezafibrate elfar brandHMDB
Bezafibrate isis brandHMDB
Bezafibrate tad brandHMDB
EulitopHMDB
Hennig brand OF bezafibrateHMDB
LipoxHMDB
SklerofibratHMDB
Teva brand OF bezafibrateHMDB
DurabezurHMDB
Azupharma brand OF bezafibrateHMDB
Beza landeHMDB
BezacurHMDB
Bezafibrate berlin-chemie brandHMDB
Bezafibrate hennig brandHMDB
Bezafibrate hexal brandHMDB
Bezafibrate merckle brandHMDB
Bezafibrate teva brandHMDB
Hexal brand OF bezafibrateHMDB
Isis brand OF bezafibrateHMDB
Lakeside brand OF bezafibrateHMDB
PB, BezafibratHMDB
SolibayHMDB
Synthelabo brand OF bezafibrateHMDB
Bayer brand OF bezafibrateHMDB
Berlin chemie brand OF bezafibrateHMDB
Berlin-chemie brand OF bezafibrateHMDB
Beza-landeHMDB
Beza-purenHMDB
Bezafibrate synthelabo brandHMDB
BezafisalHMDB
BezamerckHMDB
BéfizalHMDB
Cryopharma brand OF bezafibrateHMDB
DifaterolHMDB
Elfar brand OF bezafibrateHMDB
Merckle brand OF bezafibrateHMDB
Roche brand OF bezafibrateHMDB
AzufibratHMDB
Betapharm brand OF bezafibrateHMDB
BezaLandeHMDB
BezaPurenHMDB
BezabetaHMDB
Bezafibrate azupharma brandHMDB
Bezafibrate bayer brandHMDB
Bezafibrate betapharm brandHMDB
Bezafibrate cryopharma brandHMDB
Bezafibrate lakeside brandHMDB
Bezafibrate roche brandHMDB
Boehringer mannheim brand OF bezafibrateHMDB
ReducterolHMDB
Regadrin bHMDB
TAD brand OF bezafibrateHMDB
Chemical FormulaC19H20ClNO4
Average Molecular Mass361.819 g/mol
Monoisotopic Mass361.108 g/mol
CAS Registry Number41859-67-0
IUPAC Name2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
Traditional Namebezafibrate
SMILESCC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O
InChI IdentifierInChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
InChI KeyIIBYAHWJQTYFKB-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenoxyacetic acid derivatives. Phenoxyacetic acid derivatives are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenoxyacetic acid derivatives
Direct ParentPhenoxyacetic acid derivatives
Alternative Parents
Substituents
  • Phenoxyacetate
  • 4-halobenzoic acid or derivatives
  • Halobenzoic acid or derivatives
  • Benzoic acid or derivatives
  • Benzamide
  • Phenoxy compound
  • Phenol ether
  • Benzoyl
  • Chlorobenzene
  • Alkyl aryl ether
  • Halobenzene
  • Aryl chloride
  • Aryl halide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Ether
  • Organic nitrogen compound
  • Organohalogen compound
  • Organochloride
  • Organonitrogen compound
  • Carbonyl group
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0016 g/LALOGPS
logP3.97ALOGPS
logP3.99ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)3.83ChemAxon
pKa (Strongest Basic)-0.84ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.63 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity95.96 m³·mol⁻¹ChemAxon
Polarizability37.53 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-000l-1921000000-ed1d61965cb5663ba976Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-000i-4921000000-cf3ec530f82c5fef8a3aNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-ad4511ba17ddb3a6b528Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03k9-0049000000-319540ed864d05b5a9e8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-65fad146d0a2b8cc3aebNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0uk9-1980000000-f98f5d510895c2946e24Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-1900000000-58a247b2b13eaf401a8aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-3900000000-82a7a949824b1efdbd18Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03k9-0049000000-e56612834951c9281537Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-54280ef14ba8e69fb8fbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-1890000000-81049839e6d37ddb476aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0900000000-3ff4da4d943e21e1f3a1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-2900000000-d499986dc5288dfff06cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-62a3f94f91039648ffe1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0390000000-52f95c54ab1946e7c69fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0190000000-5257df29ed69050f426dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-ced0d5dcc71914483b64Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-849460edc8b9e96e9749Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-2392000000-f4f98f4b89b6ae9a88d1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0049000000-03924d783ef40666f558Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0019000000-58ff2df39e2672d16d49Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00n0-0945000000-47d515a6530eb8a46418Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-5b8c8d881ef997da896bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-aee3a31283069d780fdfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-673255bfbbfc965f4660Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-2900000000-3dc6146a7815f02b2566Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0019000000-f9cec491196c09ca122dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00n0-0935000000-36d012b5f26656975242Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-c01b867af88dc70e482eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-5d6c1954d400ba6b4b3aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-8a719c7882b35ef9cb54Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-2900000000-db13d869394c364ba607Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0049000000-27c256b6fd4b11f2a68aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-a8a872a7835365dc4d41Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-30327ebb215c779dcc3fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0049000000-23a7df2abaccf8e2ad58Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-0039000000-c9963bd4cd1703531d68Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-3901000000-21ede76e25f4013d242cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0913000000-a4eb50a87f9a6c722663Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-2900000000-de8aac86c461d08da59aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-1920000000-7ee255a675fedb928d0aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0910000000-cdb0a8693230271ef492Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-2090000000-139286625b6df37eda50Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03k9-0069000000-8ed2a7f1baef430aef3aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0f9l-7900000000-5475ea3caf566f1af059Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-c98f92119293a3cef8e5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-0690000000-e86382cc7c363906aabfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-1890000000-81049839e6d37ddb476aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-8a719c7882b35ef9cb54Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-0900000000-b6af557a11c3d366da8fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-0900000000-397e3e12a9527dce31f6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0049000000-0d41e48b8c1728081acdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0900000000-3ff4da4d943e21e1f3a1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-7ca6b19e6446a9d073d4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-a4a2469fc12ade5f0ae5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-849460edc8b9e96e9749Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0659000000-975e33ccb27be55fbae1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0019000000-3a78366733300f2a9312Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-2392000000-5b0413a5103c8eaa4511Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-2900000000-d499986dc5288dfff06cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0913000000-3b2cc12b18e7a7cefc61Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-c01b867af88dc70e482eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00n0-0945000000-47d515a6530eb8a46418Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-8ac99ddd8d26ec07f831Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-02vi-0029000000-69b36f108018e6ffaa08Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-5b8c8d881ef997da896bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-5d6c1954d400ba6b4b3aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0019000000-58ff2df39e2672d16d49Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00n0-0935000000-36d012b5f26656975242Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-521432f8fb27b99a360dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-0911000000-f405324e8b341d396d3bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0019000000-f9cec491196c09ca122dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-0049000000-e5969b07ef286d438cb1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-673255bfbbfc965f4660Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-3900000000-82a7a949824b1efdbd18Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03k9-0049000000-e56612834951c9281537Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-0900000000-aee3a31283069d780fdfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-1900000000-58a247b2b13eaf401a8aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0079-1900000000-0d82606046500255f6edNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-007c-3900000000-27ad98d5395b9d0447a3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0uk9-1980000000-f98f5d510895c2946e24Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-54280ef14ba8e69fb8fbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0390000000-52f95c54ab1946e7c69fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03k9-0049000000-9b10c9d9511d3aef0bcbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-2e5783381bba55e6cdb5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0190000000-5257df29ed69050f426dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0090000000-65fad146d0a2b8cc3aebNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0f9l-7900000000-01779dec27b30b07d76fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-007c-3900000000-7cffb5cc996aa31c36bfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udr-6900000000-422c71803e270c4052f4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000l-9500000000-8db9d6ce7d6c707ccc42Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0139000000-610de57b431b6eaccb80Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-07fu-3975000000-315ebcbd95638a3d3b0eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-08g0-2910000000-2d6abee2d54effe38335Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0219000000-13daa1136c7e69d084a8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ir0-0955000000-59d63587ef6ff82c5b8eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0w29-1910000000-7005220edef11728283cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0019000000-baf9d8ca6ef11a140332Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-02ti-0839000000-7c7dcf8291b9311b3e7cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0910000000-a2ff32639d8e5739f243Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0192000000-29b6018381100940d30eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00s9-9631000000-c501fa7077faf93fed6bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00lu-9610000000-940f71c2470df24ffe8cNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
1136.0Log mg/kg[640:2000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
115Drinking waterDrinking water & water supplyNot Available
298Lipid modifying agentsHealthcare, pharmaceuticals & veterinary productsNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
548Preparation Of VinegarFood, food processing & cookwareNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
655Slide FastenersTextiles, leather & furnishingsNot Available
Pathways
2 pathways
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Peroxisome proliferator-activated receptor alpha structureClick to view 3D structurePeroxisome proliferator-activated receptor alphaQ07869HumansPredicted (SEA)12.923
Peroxisome proliferator-activated receptor gamma structureClick to view 3D structurePeroxisome proliferator-activated receptor gammaP37231HumansPredicted (SEA)18.2167
Phospholipase A and acyltransferase 4 structureClick to view 3D structurePhospholipase A and acyltransferase 4Q9UL19HumansPredicted (SEA)1.01204
Click to view 3D structurePhospholipase A and acyltransferase 5Q96KN8HumansPredicted (SEA)1.01204
Phospholipase A and acyltransferase 3 structureClick to view 3D structurePhospholipase A and acyltransferase 3P53816HumansPredicted (SEA)1.01204
Phospholipase A and acyltransferase 2 structureClick to view 3D structurePhospholipase A and acyltransferase 2Q9NWW9HumansPredicted (SEA)1.01204
Click to view 3D structurePeroxisome proliferator-activated receptor alphaP23204Mus musculusPredicted (SEA)3.26967
Click to view 3D structureFatty acid-binding protein, liverP02692Rattus norvegicusPredicted (SEA)0.155698
Peroxisome proliferator-activated receptor delta structureClick to view 3D structurePeroxisome proliferator-activated receptor deltaQ03181HumansPredicted (SEA)23.4326
Cannabinoid receptor 1 structureClick to view 3D structureCannabinoid receptor 1P21554HumansPredicted (SEA)37.7569
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)280.724
Glucagon receptor structureClick to view 3D structureGlucagon receptorP47871HumansPredicted (SEA)83.3765
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)402.169
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)276.676
Click to view 3D structureUncharacterized proteinA0A8I3N355Canis lupus familiarisPredicted (SEA)3.19182
Gastric inhibitory polypeptide receptor structureClick to view 3D structureGastric inhibitory polypeptide receptorP48546HumansPredicted (SEA)73.5675
Click to view 3D structureGlucagon receptorP30082Rattus norvegicusPredicted (SEA)79.2505
Glucagon-like peptide 1 receptor structureClick to view 3D structureGlucagon-like peptide 1 receptorP43220HumansPredicted (SEA)102.995
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)152.818
Mitogen-activated protein kinase kinase kinase kinase 4 structureClick to view 3D structureMitogen-activated protein kinase kinase kinase kinase 4O95819HumansPredicted (SEA)316.379
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)151.027
Click to view 3D structureMisshapen-like kinase 1Q8N4C8HumansPredicted (SEA)254.022
Click to view 3D structureGlucagon receptorQ61606Mus musculusPredicted (SEA)84.0772
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)372.586
Bifunctional epoxide hydrolase 2 structureClick to view 3D structureBifunctional epoxide hydrolase 2P34913HumansPredicted (SEA)53.7938
Concentrations
StatusValueUnitSample LocationReference
Detected and Quantified470ng/LBioggio,Lugano
Detected and Quantified1500ng/LBussigny-prés-Lausanne
Detected and Quantified190ng/LHallau,Klettgau
Detected and Quantified53ng/LThal,Altenrhein
Detected and Quantified320ng/LUetendorf,Thun
Detected and Quantified270ng/LVernier,Aïre
Detected and Quantified59ng/LWinterthur
Detected and Quantified160ng/LWerdhölzli,Zürich
Detected and Quantified33ng/LSchönau,Zug
Detected and Quantified49ng/LAffoltern,Zwillikon
External Links
DrugBank IDDB01393
HMDB IDHMDB0015465
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDPEM
Wikipedia LinkBezafibrate
Chemspider ID35728
ChEBI ID47612
PubChem Compound ID39042
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. Authors unspecified: Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. Circulation. 2000 Jul 4;102(1):21-7.
2. Tenenbaum A, Motro M, Fisman EZ, Schwammenthal E, Adler Y, Goldenberg I, Leor J, Boyko V, Mandelzweig L, Behar S: Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation. 2004 May 11;109(18):2197-202. Epub 2004 May 3.
3. Tenenbaum A, Motro M, Fisman EZ, Tanne D, Boyko V, Behar S: Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. Arch Intern Med. 2005 May 23;165(10):1154-60.
4. Tenenbaum A, Fisman EZ, Boyko V, Benderly M, Tanne D, Haim M, Matas Z, Motro M, Behar S: Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate. Arch Intern Med. 2006 Apr 10;166(7):737-41.
5. MEDSAFE: http://www.medsafe.govt.nz/profs/datasheet/f/fibaliptab.pdf
6. https://www.ncbi.nlm.nih.gov/pubmed/?term=17379010
7. https://www.ncbi.nlm.nih.gov/pubmed/?term=18787029
8. https://www.ncbi.nlm.nih.gov/pubmed/?term=19131462