Beclazone (CED0003348)

Record Information
Version1.0
Creation Date2016-05-22 06:39:17 UTC
Update Date2026-08-22 08:31:18 UTC
Accession NumberCHEM019955
Identification
Common NameBeclazone
ClassSmall Molecule
Description
Beclazone belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. With an average molecular weight of 521.04 g/mol, Beclazone is a heavy molecule. Its chemical formula is C28H37ClO7. The compound is found in or released from 33 recorded sources. Within the category of healthcare, pharmaceuticals, and veterinary products, it is used as an intestinal antiinflammatory agent, as a corticosteroid, in corticosteroid combinations with antibiotics, in nasal preparations, and as a drug for obstructive airway diseases. Other recorded sources include electrical and electronic equipment, such as amplifiers, antennas, auxiliary devices, discharge lamps, and electric switches. It is also associated with building and construction materials, specifically roofs, stairs, and ramps. In the realm of food, food processing, and cookware, it is linked to the processing of meats and fish, as well as the preparation of wort, wine or sparkling wine, and fermentation processes for beer. Additionally, it is found in household cleaning and consumer products, including pipe accessories, tobacco smoke filters, cigar cigarettes, and non-electric simulated smoking devices. Recorded exposure routes for Beclazone include topical, nasal, and respiratory pathways. Beclazone interacts with four recorded protein targets. It acts as an agonist or modulator of the glucocorticoid receptor (NR3C1) and targets steroid hormone receptors ERR1 (ESRRA) and ERR2 (ESRRB), as well as the estrogen-related receptor gamma (ESRRG).
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
(11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dioneChEBI
9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateChEBI
9-Chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionateChEBI
AerobecChEBI
AldecinChEBI
AnceronChEBI
AndionChEBI
BeclacinChEBI
BecloforteChEBI
BeclometChEBI
Beclometasone 17,21-dipropionateChEBI
BeclorhinolChEBI
BeclovalChEBI
BecloventChEBI
BecodisksChEBI
BeconaseChEBI
BeconasolChEBI
BecotideChEBI
Clenil-aChEBI
EntydermaChEBI
InaloneChEBI
KorbutoneChEBI
PropadermChEBI
Rino-clenilChEBI
SanasthmaxChEBI
SanasthmylChEBI
VancenaseChEBI
VancerilChEBI
ViarexChEBI
ViaroxChEBI
QnaslKegg
(11b,16b)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dioneGenerator
(11Β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dioneGenerator
9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateGenerator
9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
9-Chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateGenerator
9-Chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
9-Chloro-16b-methyl-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionateGenerator
9-Chloro-16b-methyl-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
9-Chloro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
9-Chloro-16β-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionateGenerator
9-Chloro-16β-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionic acidGenerator
Beclometasone 17,21-dipropionic acidGenerator
Beclometasone dipropionic acidGenerator
Beclomethasone dipropionateHMDB
3m Brand OF beclomethasone dipropionateHMDB
Asche brand OF beclomethasone dipropionateHMDB
Asmabec clickhalerHMDB
BeclocortHMDB
Medeva brand OF beclomethasone dipropionateHMDB
Orion brand OF beclomethasone dipropionateHMDB
AeroBec forteHMDB
Allen and hanburys brand OF beclomethasone dipropionateHMDB
Apotex brand OF beclomethasone dipropionateHMDB
AscocortonylHMDB
BeclametHMDB
Beclo azuHMDB
BecloturmantHMDB
FilairHMDB
Norton brand OF beclomethasone dipropionateHMDB
ProlairHMDB
Schering-plough brand OF beclomethasone dipropionateHMDB
Aldo brand OF beclomethasone dipropionateHMDB
Azupharma brand OF beclomethasone dipropionateHMDB
Beclo asmaHMDB
BeclometasoneHMDB
BeclomethasoneHMDB
Beconase aqHMDB
Dipropionate, beclomethasoneHMDB
Filair forteHMDB
Fujisawa brand OF beclomethasone dipropionateHMDB
Glaxo wellcome brand OF beclomethasone dipropionateHMDB
GlaxoSmithKline brand 1 OF beclomethasone dipropionateHMDB
GlaxoSmithKline brand 3 OF beclomethasone dipropionateHMDB
JunikHMDB
Nasobec aqueousHMDB
RespocortHMDB
Shire brand OF beclomethasone dipropionateHMDB
BecodiskHMDB
QvarHMDB
Schering brand 1 OF beclomethasone dipropionateHMDB
United drug brand OF beclomethasone dipropionateHMDB
a And H brand OF beclomethasone dipropionateHMDB
Apo-beclomethasoneHMDB
BeclazoneHMDB
Beclazone easy breatheHMDB
Bemedrex easyhalerHMDB
BronchocortHMDB
Celltech brand OF beclomethasone dipropionateHMDB
EcobecHMDB
GlaxoSmithKline brand 2 OF beclomethasone dipropionateHMDB
Ivax brand OF beclomethasone dipropionateHMDB
Schering brand 2 OF beclomethasone dipropionateHMDB
VentolairHMDB
ViarinHMDB
Beclomethasone dipropionic acidHMDB
Beclometasone dipropionateChEBI
Chemical FormulaC28H37ClO7
Average Molecular Mass521.042 g/mol
Monoisotopic Mass520.223 g/mol
CAS Registry Number5534-09-8
IUPAC Name2-[(1R,2S,10S,11S,13S,14R,15S,17S)-1-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate
Traditional Namebeconase
SMILES[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
InChI IdentifierInChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
InChI KeyKUVIULQEHSCUHY-XYWKZLDCSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassPregnane steroids
Direct ParentGluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Substituents
  • Progestogin-skeleton
  • Steroid ester
  • 20-oxosteroid
  • 3-oxo-delta-1,4-steroid
  • 3-oxosteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • 9-halo-steroid
  • Halo-steroid
  • Hydroxysteroid
  • Delta-1,4-steroid
  • Alpha-acyloxy ketone
  • Dicarboxylic acid or derivatives
  • Cyclic alcohol
  • Carboxylic acid ester
  • Chlorohydrin
  • Cyclic ketone
  • Secondary alcohol
  • Halohydrin
  • Ketone
  • Carboxylic acid derivative
  • Alcohol
  • Hydrocarbon derivative
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Organooxygen compound
  • Organochloride
  • Organohalogen compound
  • Alkyl chloride
  • Alkyl halide
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0021 g/LALOGPS
logP3.69ALOGPS
logP4.43ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)13.85ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area106.97 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity134.79 m³·mol⁻¹ChemAxon
Polarizability54.41 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-00pi-7931200000-ebf9cfbf75bf09c67c7aNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0bvi-9427050000-eb3614d4b3688b88c0c8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000f-0930000000-081eac0a05abab8fc5faNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000f-0930000000-081eac0a05abab8fc5faNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3920000000-d6e2b1ac89621299e6bbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0536-0000390000-d1146b326a2bf27937e3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0489240000-9581961e5dddfb7a403fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0h71-3892000000-454fb634c4339a1ebfe0Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0kmj-4001960000-2444d4d01b60622dc9daNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-9016710000-03228f1ad114124f50a8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ab9-7259300000-8a403afc0efa6ee4f110Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0600-9000440000-d5250fc13ae4ff60aa89Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-05fr-9001300000-fb71d87f62527dae4806Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-05fr-9002000000-182d2c80d6e083b565f0Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009730000-81e60ed81d61c6314c37Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-01xx-0009200000-d06a88f89fcfe1e37e3fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-9627500000-178854364472c3c4dd81Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-9006200000-345f47155712cbf26442Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-05fr-9003000000-fa1ac5e3b880b5467f13Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ab9-9000000000-89a0f1c5a6da8df63c3cNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
2052.0Log mg/kg[1200:3600]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
233BrushesPersonal care & cosmeticsNot Available
258Intestinal antiinflammatory agentsHealthcare, pharmaceuticals & veterinary productsNot Available
309CorticosteroidsHealthcare, pharmaceuticals & veterinary productsNot Available
311Corticosteroids, combinations with antibioticsHealthcare, pharmaceuticals & veterinary productsNot Available
389Nasal preparationsHealthcare, pharmaceuticals & veterinary productsNot Available
391Drugs for obstructive airway diseasesHealthcare, pharmaceuticals & veterinary productsNot Available
499RoofsBuilding & ConstructionNot Available
500Stairs And RampsBuilding & ConstructionNot Available
505AmplifiersElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
507Auxiliary DevicesElectrical & Electronic EquipmentNot Available
514Discharge LampsElectrical & Electronic EquipmentNot Available
517Electric SwitchesElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
521Fixed Capacitors And Their ManufactureElectrical & Electronic EquipmentNot Available
525Line Transmission SystemsElectrical & Electronic EquipmentNot Available
527MagnetsElectrical & Electronic EquipmentNot Available
530Radio Transmission SystemsElectrical & Electronic EquipmentNot Available
531RelaysElectrical & Electronic EquipmentNot Available
533Sparking PlugsElectrical & Electronic EquipmentNot Available
535Superconducting Magnets And Superconducting CoilsElectrical & Electronic EquipmentNot Available
537Television SystemsElectrical & Electronic EquipmentNot Available
538Thin Magnetic FilmsElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
544Fermentation Processes For BeerFood, food processing & cookwareNot Available
549Preparation Of Wine Or Sparkling WineFood, food processing & cookwareNot Available
550Preparation Of WortFood, food processing & cookwareNot Available
551Processing FishFood, food processing & cookwareNot Available
552Processing MeatsFood, food processing & cookwareNot Available
556Cigar CigarettesHousehold cleaning & consumer productsNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
560Other Smoking RequisitesHousehold cleaning & consumer productsNot Available
562Pipe AccessoriesHousehold cleaning & consumer productsNot Available
569Tobacco Smoke FiltersHousehold cleaning & consumer productsNot Available
579Manufacture Of Iron Or SteelIndustrial manufacturing & chemical processingNot Available
581Paper Making MachinesIndustrial manufacturing & chemical processingNot Available
583Anchoring EquipmentMarine, shipping & aquacultureNot Available
590Lifeboat EquipmentMarine, shipping & aquacultureNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
601Lawn MowersAgriculture & land managementNot Available
605Pest RepellantsAgriculture & land managementNot Available
607Rodenticides(1)Agriculture & land managementNot Available
608RodenticidesAgriculture & land managementNot Available
609AftershavePersonal care & cosmeticsNot Available
610Aftersun ProductsPersonal care & cosmeticsNot Available
612Body Washing Or Cleaning ImplementsPersonal care & cosmeticsNot Available
613DepilatoriesPersonal care & cosmeticsNot Available
616Face Mask CosmeticsPersonal care & cosmeticsNot Available
617Lip Care ProductsPersonal care & cosmeticsNot Available
624Merry Go RoundsRecreation & sports surfacesNot Available
630ToysRecreation & sports surfacesNot Available
638Decorating TextilesTextiles, leather & furnishingsNot Available
642FootwearTextiles, leather & furnishingsNot Available
649Pins ClothesTextiles, leather & furnishingsNot Available
650Purses Luggage Hand BagsTextiles, leather & furnishingsNot Available
653SewingTextiles, leather & furnishingsNot Available
661UmbrellasTextiles, leather & furnishingsNot Available
662Yarns Or ThreadsTextiles, leather & furnishingsNot Available
Pathways
2 pathways
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Glucocorticoid receptor structureClick to view 3D structureGlucocorticoid receptorP04150HumansPredicted (SEA)2.33548
Click to view 3D structureTyrosine aminotransferaseP04694Rattus norvegicusPredicted (SEA)0.155698
Progesterone receptor structureClick to view 3D structureProgesterone receptorP06401HumansPredicted (SEA)3.58106
Interstitial collagenase structureClick to view 3D structureInterstitial collagenaseP03956HumansPredicted (SEA)27.3251
Click to view 3D structureProgesterone receptorQ690N0Bos taurusPredicted (SEA)2.95827
Click to view 3D structureGlucocorticoid receptorP06536Rattus norvegicusPredicted (SEA)2.49118
Click to view 3D structureAndrogen receptorP15207Rattus norvegicusPredicted (SEA)12.4559
Bile salt export pump structureClick to view 3D structureBile salt export pumpO95342HumansPredicted (SEA)8.25202
Mineralocorticoid receptor structureClick to view 3D structureMineralocorticoid receptorP08235HumansPredicted (SEA)22.187
Click to view 3D structureNuclear receptor subfamily 1 group I member 2Q9R1A7Rattus norvegicusPredicted (SEA)0.622794
Pyruvate carboxylase, mitochondrial structureClick to view 3D structurePyruvate carboxylase, mitochondrialP11498HumansPredicted (SEA)0.389246
Androgen receptor structureClick to view 3D structureAndrogen receptorP10275HumansPredicted (SEA)67.5731
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)1875.23
Estrogen receptor structureClick to view 3D structureEstrogen receptorP03372HumansPredicted (SEA)138.883
Protein kinase C delta type structureClick to view 3D structureProtein kinase C delta typeQ05655HumansPredicted (SEA)1038.74
Protein kinase C eta type structureClick to view 3D structureProtein kinase C eta typeP24723HumansPredicted (SEA)228.565
Protein kinase C epsilon type structureClick to view 3D structureProtein kinase C epsilon typeQ02156HumansPredicted (SEA)341.057
Protein kinase C alpha type structureClick to view 3D structureProtein kinase C alpha typeP17252HumansPredicted (SEA)358.963
Estrogen receptor beta structureClick to view 3D structureEstrogen receptor betaQ92731HumansPredicted (SEA)220.08
Solute carrier organic anion transporter family member 1B1 structureClick to view 3D structureSolute carrier organic anion transporter family member 1B1Q9Y6L6HumansPredicted (SEA)48.5779
Solute carrier organic anion transporter family member 1B3 structureClick to view 3D structureSolute carrier organic anion transporter family member 1B3Q9NPD5HumansPredicted (SEA)37.3676
cAMP-dependent protein kinase catalytic subunit alpha structureClick to view 3D structurecAMP-dependent protein kinase catalytic subunit alphaP17612HumansPredicted (SEA)1956.35
Rho-associated protein kinase 2 structureClick to view 3D structureRho-associated protein kinase 2O75116HumansPredicted (SEA)2153.15
Rho-associated protein kinase 1 structureClick to view 3D structureRho-associated protein kinase 1Q13464HumansPredicted (SEA)2265.8
RAC-alpha serine/threonine-protein kinase structureClick to view 3D structureRAC-alpha serine/threonine-protein kinaseP31749HumansPredicted (SEA)2182.81
Concentrations
Not Available
External Links
DrugBank IDDB00394
HMDB IDHMDB0014538
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkBeclometasone_dipropionate
Chemspider ID20396
ChEBI ID3002
PubChem Compound ID21700
Kegg Compound IDC07813
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=12938103
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=16920559
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=18694371
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=19747642
5. Willey RF, Milne LJ, Crompton GK, Grant IW: Beclomethasone dipropionate aerosol and oropharyngeal candidiasis. Br J Dis Chest. 1976 Jan;70(1):32-8.
6. Salzman GA, Pyszczynski DR: Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol. 1988 Feb;81(2):424-8.
7. Fukushima C, Matsuse H, Tomari S, Obase Y, Miyazaki Y, Shimoda T, Kohno S: Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. Ann Allergy Asthma Immunol. 2003 Jun;90(6):646-51.
8. Castilla C, Perez-Simon JA, Sanchez-Guijo FM, Diez-Campelo M, Ocio E, Perez-Persona E, Lopez-Villar O, Vazquez L, Caballero D, San Miguel JF: Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). Biol Blood Marrow Transplant. 2006 Sep;12(9):936-41.
9. Hockenbery DM, Cruickshank S, Rodell TC, Gooley T, Schuening F, Rowley S, David D, Brunvand M, Berryman B, Abhyankar S, Bouvier M, McDonald GB: A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. Blood. 2007 May 15;109(10):4557-63. Epub 2007 Jan 23.
10. Astegiano M, Pagano N, Sapone N, Simondi D, Bertolusso L, Bresso F, Demarchi B, Pellicano R, Bonardi R, Marconi S, Rizzetto M: Efficacy and safety of oral beclomethasone dipropionate for ileal or ileal-right colon Crohn's disease of mild-to-moderate activity or in remission: Retrospective study. Biomed Pharmacother. 2007 Jul;61(6):370-6. Epub 2007 Mar 12.
11. McDonald GB: Oral beclomethasone dipropionate: a topically active corticosteroid for the treatment of gastrointestinal graft-versus-host disease following allogeneic hematopoietic cell transplantation. Expert Opin Investig Drugs. 2007 Oct;16(10):1709-24.
12. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9.
13. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10.
14. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20.
15. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621.
16. FDA label.
17. The lipid handbook with CD-ROM