Aldosterone (CED0000952)

Aldosterone (C21H28O5) is a compound with an average molecular weight of 360.44 g/mol. Aldosterone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound acts as an agonist or blocker for three protein targets: the Mineralocorticoid receptor (NR3C2), the Glucocorticoid receptor (NR3C1), and Solute carrier family 12 member 1 (SLC12A1). The substance is found in or released from 27 recorded sources, including medical devices from the healthcare, pharmaceuticals & veterinary products sector; drinking water from the drinking water & water supply sector; synthetic textiles, carpets and rugs from the textiles, leather & furnishings sector; and food packaging and food preservation from the food, food processing & cookware sector. Other sources include perfumes within detergents and soaps, bleaching agents, cigar cigarettes, and other smoking requisites from household cleaning & consumer products, as well as batteries, capacitors, cell phones, wires and cables, and printed circuit boards from electrical & electronic equipment. Recorded exposure routes include touch, oral, and inhalation. Aldosterone is associated with several health effects, including essential hypertension (PMC11010091), an increase in inflammation (PMC9622620), an increase in blood pressure (PMC9622620), an increase in stroke (PMC9622620), and an increase in atherosclerosis (PMC11351257). Furthermore, blood levels of the compound are elevated in cases of hypertension (PMC5552154) and heart failure (PMC3570174).