Serotonin (CED0000651)

Record Information
Version1.0
Creation Date2016-05-25 18:10:20 UTC
Update Date2026-05-14 19:00:02 UTC
SynCED IDCED0000651
Secondary Accession Numbers
  • CHEM021698
Identification
Common NameSerotonin
ClassSmall Molecule
Description
Serotonin (C10H12N2O) is an organic compound with an average molecular weight of 176.22 g/mol. Serotonin belongs to the tryptamines and derivatives, a subclass of indoles and derivatives within the organic compounds. Biologically, it functions as a neurotransmitter (PMC10170285 , PMC10979413 ) and an agonist (PMC3477246 ). It is an inhibitor of 15 recorded protein targets, including the Sodium-dependent serotonin transporter (SLC6A4), 5-hydroxytryptamine receptor 2A (HTR2A), 5-hydroxytryptamine receptor 3A (HTR3A), and 5-hydroxytryptamine receptor 3B (HTR3B). The compound is found in or released from 34 recorded sources, including medical devices, lubricants, synthetic textiles, carpets and rugs, food packaging, food preservation, preparation of vinegar, and preparation of wort. Other sources include cell phones, capacitors, wires and cables, batteries, printed circuit boards, cigar cigarettes, non electric simulated smoking devices, other smoking requisites, perfumes within detergents and soaps, and pipe accessories. Recorded exposure routes include oral, touch, and inhalation. Serotonin is associated with several health effects, including osteoporosis (PMC10532995 ), pain (PMC11369511 , PMC5962350 ), chronic pain (PMC12027284 ), insomnia (PMC12027284 ), inflammation (PMC8213022 ), and schizophrenia (PMC3774751 , PMC7112550 ). It is associated with depression (PMC10662300 , PMC11043594 ), anxiety (PMC12562881 , PMC13386386 ), an increase in anxiety (PMC12027284 , PMC12691759 ), and an increase in hypertension (PMC13409969 ). Decreased blood levels of the compound are noted in depression (PMC12562881 , PMC13198951 ) and decreased anxiety (PMC12562881 ). Additionally, serotonin has a therapeutic effect on hypertension (PMC6175881 ) and inflammation (PMC11548868 ).
Contaminant Type
  • PFAS
  • Phytotoxin
Chemical Structure
Synonyms
ValueSource
3-(2-Aminoethyl)-1H-indol-5-olChEBI
5-HTChEBI
5-HydroxytryptamineChEBI
EnteramineChEBI
SerotonineChEBI
ThrombocytinChEBI
ThrombotoninChEBI
HippophaineHMDB
HydroxytryptamineHMDB
5 HydroxytryptamineHMDB
3-(2-Aminoethyl)indol-5-olHMDB
3-(b-Aminoethyl)-5-hydroxyindoleHMDB
5-HTAHMDB
5-Hydroxy-3-(b-aminoethyl)indoleHMDB
5-Hydroxy-tryptamineHMDB
5-HydroxyltryptamineHMDB
5-HydroxytriptamineHMDB
AntemovisHMDB
DS SubstanceHMDB
EnteraminHMDB
Chemical FormulaC10H12N2O
Average Molecular Mass176.215 g/mol
Monoisotopic Mass176.095 g/mol
CAS Registry Number50-67-9
IUPAC Name3-(2-aminoethyl)-1H-indol-5-ol
Traditional Nameserotonin
SMILESNCCC1=CNC2=CC=C(O)C=C12
InChI IdentifierInChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChI KeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as serotonins. Serotonins are compounds containing a serotonin moiety, which consists of an indole that bears an aminoethyl a position 2 and a hydroxyl group at position 5.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassTryptamines and derivatives
Direct ParentSerotonins
Alternative Parents
Substituents
  • Serotonin
  • 3-alkylindole
  • Hydroxyindole
  • Indole
  • 2-arylethylamine
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Substituted pyrrole
  • Benzenoid
  • Pyrrole
  • Heteroaromatic compound
  • Azacycle
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Amine
  • Organic oxygen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility2.5 g/LALOGPS
logP0.56ALOGPS
logP0.48ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)9.31ChemAxon
pKa (Strongest Basic)10ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area62.04 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity52.35 m³·mol⁻¹ChemAxon
Polarizability19.31 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
GC-MSGC-MS Spectrumsplash10-00di-1900000000-461c2a1f67418e6b5d6aNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-2286e87324e9f4a78cb4Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-927b865023cbba872101Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1910000000-02c17b4cd3336a8bf9b1Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-8900000000-4b838943ace80c8b7734Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-6900000000-a7dd5c569cf4d085d244Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-0900000000-2346e553f96cb980c8fcNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-01fbd5196188d4e0f21cNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0002-9800000000-9ce9fb2286c3b7ea7719Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-461c2a1f67418e6b5d6aNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-2286e87324e9f4a78cb4Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-927b865023cbba872101Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1910000000-02c17b4cd3336a8bf9b1Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-8900000000-4b838943ace80c8b7734Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-6900000000-a7dd5c569cf4d085d244Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-0900000000-2346e553f96cb980c8fcNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-1900000000-01fbd5196188d4e0f21cNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-001j-6900000000-95a89ff8a3b12e7e8e25Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-001i-9450000000-52e0b628b7795c643362Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-6acaf73bcd452e24b886Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aor-0900000000-259227b20b82e6362059Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-02e9-5900000000-2f58fbed270523182158Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9800000000-abcd0769bb17d07b3e38Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-bf65d809200ea387ebf5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-8a171ac4fdc0474f7f48Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03xr-0900000000-a0b7d8a671909c6f4ad1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-1900000000-fa80d05236eabbafd678Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-4900000000-4e2e322d56fc9ee00eddNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-0900000000-c79f0b03a8dc1da0a10aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03fr-0900000000-9cb056cd56bae76589d0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-1900000000-d64210214a1b3766ff6eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-08840bc938c367dacbb2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03yi-0900000000-858936972fd87c0c0b14Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0159-4900000000-a8fc7dff385a4f51b88aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00p0-9400000000-7e4063d2b516ae59df84Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-bf65d809200ea387ebf5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-8a171ac4fdc0474f7f48Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03xr-0900000000-a0b7d8a671909c6f4ad1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-1900000000-e470cd23466404f9bf5bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-4900000000-d242a2269e10d5bc922eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-a99d60699d7b9ffba28cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-0900000000-c79f0b03a8dc1da0a10aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03fr-0900000000-9cb056cd56bae76589d0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-77d500913f76964f7f0eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03yi-0900000000-daac49477fa56cf0dfb7Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-003r-1900000000-ad156cb66bb11c92c4aaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03fr-0900000000-3f7db2c4b0908fead689Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-08840bc938c367dacbb2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-7efb3791e3209a68069aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-2b961b688ccf332ee88aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00p0-9400000000-2ce0b0bf4bd197fbf616Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-22d267ecc569166333d5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03yi-0900000000-c95266122d3f6233701dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00p0-9400000000-2616407fe9ec3bbd71ebNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0159-4900000000-01322b19286659fd280aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-97232d66584e43e6a10aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-3900000000-ef7670aa507d1096f754Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-4900000000-ff4e5124e0d5fc3b9710Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-4bf13ae5b7782581e587Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-bf8a50ec2d6281e23a16Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03yi-0900000000-39bdedb62e66ba823b9cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0159-4900000000-c525ed7b9993d4dee721Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-97db378b61d6e579f607Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-016r-5900000000-07f35912ccf8a42bca7cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-ad1af7bec369de58b41cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00p0-9400000000-323f4b14f2b30ce7ca97Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-a1a13044b82c41619a49Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-1900000000-66be80bf04de85d374b7Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-0900000000-662e21ddee556bb4a222Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-0900000000-337ec7823cec887c8ad3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004i-0900000000-8ac1f8742228b0c2ada5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00os-4900000000-fe28a76e9223ea9c3912Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-9200000000-faf92490b8049363f990Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-9500000000-c65e4440ede6c6f45d71Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-45617dcfc05b8378b8c0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-4900000000-c53fbb9d8708bc918d3eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-01t9-0900000000-a4e556450f24165aed15Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0900000000-657c360c251ec5745d1fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-01qc-2900000000-397a6873ea727da9cc8fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0900000000-253552852dde8abefca0Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0900000000-5dd492dfc2d781e72254Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-053r-1900000000-bed3bfffbc9cca506281Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0900000000-6e0f5e708c1990d5d956Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-003r-0900000000-c1a4f85fae5f1e669122Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001l-2900000000-96b6bc38e36288700a4fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-01t9-0900000000-4bf0ef18457bfebaa585Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0900000000-eccce5a9e47d626b0050Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000x-2900000000-1ab770b2e51be03ad91aNot AvailableView Spectrum
1D NMR1H NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
1D NMR13C NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
235.0 Log mg/kg [130:420]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
hypertensionAssociated With?increaseA disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. (NCI CTCAE)PMC13409969
hypertensionHas Therapeutic Effect OnNot AvailableA disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. (NCI CTCAE)PMC6175881
inflammationHas Therapeutic Effect OnNot AvailableNot AvailablePMC11548868
inflammationAssociated With?Not AvailableNot AvailablePMC8213022
insomniaAssociated With?Not AvailableA disorder characterized by difficulty in falling asleep and/or remaining asleep. (NCI CTCAE)PMC12027284
osteoporosisAssociated With?Not AvailableA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. (NCI CTCAE)PMC10532995
painAssociated With?Not AvailableA disorder characterized by the sensation of marked discomfort, distress or agony. (NCI CTCAE)PMC11369511 , PMC5962350
chronic painAssociated With?Not AvailableA state in which pain lasts for several weeks or months and may increase in severity.PMC12027284
schizophreniaAssociated With?Not AvailableA psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (DO)PMC3774751 , PMC7112550
anxietyAssociated With?increaseA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. (NCI CTCAE)PMC12027284 , PMC12027284
anxietyDecreased in Blood IndecreaseA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. (NCI CTCAE)PMC12562881
anxietyAssociated With?Not AvailableA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. (NCI CTCAE)PMC12562881 , PMC13386386
depressionAssociated With?Not AvailableNot AvailablePMC10662300 , PMC11043594
depressionDecreased in Blood InNot AvailableNot AvailablePMC12562881 , PMC13198951
migraineAssociated With?Not AvailableA brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. (DO)PMC11844069 , PMC4836167
ulcerative colitisAssociated With?decreaseA health condition characterized by inflammation of the colon. A type of IBD.PMC8213022
irritable bowel syndromeAssociated With?Not AvailableA syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. (DO)PMC12027284
fibromyalgiaDecreased in Blood IndecreaseA disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues.PMC9556195
Exposure Sources
Source IDSourceSectorReference
CEDs000007Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementPubChem
CEDs000120Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.Electrical & Electronic EquipmentNot Available
CEDs000121Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.Electrical & Electronic EquipmentNot Available
CEDs000125Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.Electrical & Electronic EquipmentNot Available
CEDs000130Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.Electrical & Electronic EquipmentNot Available
CEDs000138Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.Energy, oil & gasNot Available
CEDs000147Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.Food, food processing & cookwareNot Available
CEDs000174Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.Industrial manufacturing & chemical processingNot Available
CEDs000234Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000451Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.Textiles, leather & furnishingsNot Available
CEDs000454Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.Textiles, leather & furnishingsNot Available
CEDs000490Personal care & cosmeticsNot Available
CEDs000492Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.Electrical & Electronic EquipmentNot Available
CEDs000493Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.Electrical & Electronic EquipmentNot Available
CEDs000505Amplifiers?Amplifiers, commonly used in various electronic devices to enhance signal strength, can be a source of synthetic chemical contamination due to the materials and processes involved in their production and disposal.Electrical & Electronic EquipmentPubChem
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentPubChem
CEDs000516Electric Hearing Aids?Electric hearing aids are small electronic devices designed to amplify sound for individuals with hearing loss.Electrical & Electronic EquipmentPubChem
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentPubChem
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentPubChem
CEDs000520Emergency Protective Devices?Emergency protective devices, such as circuit breakers and surge protectors, are essential components in electrical systems designed to prevent damage from overcurrent and surges.Electrical & Electronic EquipmentPubChem
CEDs000524Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.Electrical & Electronic EquipmentPubChem
CEDs000530Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.Electrical & Electronic EquipmentPubChem
CEDs000534Still Video Cameras?Still video cameras, which capture images in digital format, can be a source of synthetic chemical contamination due to the materials and components used in their production and operation.Electrical & Electronic EquipmentPubChem
CEDs000538Thin Magnetic Films?Thin magnetic films are layers of magnetic material ranging from a few nanometers to several micrometers in thickness, commonly used in applications such as magnetic sensors, data storage devices, and electronic components.Electrical & Electronic EquipmentPubChem
CEDs000539Video Games?Video games, through their production and disposal processes, can be a source of synthetic chemical contamination.Electrical & Electronic EquipmentPubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000548Preparation Of Vinegar?Vinegar is produced through the fermentation of ethanol by acetic acid bacteria, resulting in a solution that typically contains 4-8% acetic acid.Food, food processing & cookwarePubChem
CEDs000550Preparation Of Wort?The preparation of wort involves the extraction of sugars from malted grains, a crucial step in the brewing process.Food, food processing & cookwarePubChem
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsPubChem
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsPubChem
CEDs000560Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000562Pipe Accessories?Pipe accessories, such as fittings, connectors, and seals, are components used in plumbing systems to facilitate the flow of liquids and gases.Household cleaning & consumer productsPubChem
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsPubChem
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsPubChem
CEDs000578Making Cigars?The process of making cigars involves several steps, including the cultivation of tobacco, fermentation, and the application of various additives to enhance flavor and preservation.Industrial manufacturing & chemical processingPubChem
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingPubChem
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementPubChem
CEDs000605Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.Agriculture & land managementPubChem
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementPubChem
CEDs000609Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.Personal care & cosmeticsPubChem
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsPubChem
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsPubChem
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsPubChem
CEDs000642Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.Textiles, leather & furnishingsPubChem
CEDs000662Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.Textiles, leather & furnishingsPubChem
CEDs000679Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.Agriculture & land managementPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000688Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.Building & ConstructionPubChem
CEDs000695Treatment Of Milk Or Cream?The treatment of milk or cream involves various processes such as pasteurization, homogenization, and the addition of preservatives to enhance shelf life and safety.Food, food processing & cookwarePubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructurePubChem
CEDs000738Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.Industrial manufacturing & chemical processingPubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
131 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansPredicted (SEA)
Prediction Confidence Score
0.801
Applicability Domain
1.0
Statistical Significance
2.00e-05
Supporting Reference Compounds
823
E-value
0.155698
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)
Prediction Confidence Score
0.788
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
955
E-value
0.0778492
5-hydroxytryptamine receptor 1A structureClick to view 3D structure5-hydroxytryptamine receptor 1AP08908HumansPredicted (SEA)
Prediction Confidence Score
0.77
Applicability Domain
1.0
Statistical Significance
9.00e-05
Supporting Reference Compounds
953
E-value
0.700643
Click to view 3D structure5-hydroxytryptamine receptor 1AP19327Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.729
Applicability Domain
1.0
Statistical Significance
2.20e-04
Supporting Reference Compounds
541
E-value
1.71268
Click to view 3D structure5-hydroxytryptamine receptor 1BP28564Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.729
Applicability Domain
1.0
Statistical Significance
2.00e-05
Supporting Reference Compounds
154
E-value
0.155698
Click to view 3D structureSodium-dependent serotonin transporterP31652Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.715
Applicability Domain
1.0
Statistical Significance
8.00e-05
Supporting Reference Compounds
297
E-value
0.622794
5-hydroxytryptamine receptor 2B structureClick to view 3D structure5-hydroxytryptamine receptor 2BP41595HumansPredicted (SEA)
Prediction Confidence Score
0.707
Applicability Domain
1.0
Statistical Significance
1.10e-04
Supporting Reference Compounds
686
E-value
0.856341
5-hydroxytryptamine receptor 1D structureClick to view 3D structure5-hydroxytryptamine receptor 1DP28221HumansPredicted (SEA)
Prediction Confidence Score
0.7
Applicability Domain
1.0
Statistical Significance
1.00e-04
Supporting Reference Compounds
365
E-value
0.778492
5-hydroxytryptamine receptor 1B structureClick to view 3D structure5-hydroxytryptamine receptor 1BP28222HumansPredicted (SEA)
Prediction Confidence Score
0.686
Applicability Domain
1.0
Statistical Significance
1.10e-04
Supporting Reference Compounds
337
E-value
0.856341
5-hydroxytryptamine receptor 7 structureClick to view 3D structure5-hydroxytryptamine receptor 7P34969HumansPredicted (SEA)
Prediction Confidence Score
0.677
Applicability Domain
1.0
Statistical Significance
2.60e-04
Supporting Reference Compounds
565
E-value
2.02408
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansPredicted (SEA)
Prediction Confidence Score
0.674
Applicability Domain
1.0
Statistical Significance
1.20e-04
Supporting Reference Compounds
536
E-value
0.934191
Click to view 3D structure5-hydroxytryptamine receptor 7P32305Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.657
Applicability Domain
1.0
Statistical Significance
7.00e-05
Supporting Reference Compounds
115
E-value
0.544945
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP08909RatPredicted (SEA)
Prediction Confidence Score
0.644
Applicability Domain
1.0
Statistical Significance
2.00e-04
Supporting Reference Compounds
185
E-value
1.55698
Click to view 3D structureNorepinephrine transporterQ9WTR4Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.633
Applicability Domain
0.657
Statistical Significance
1.60e-04
Supporting Reference Compounds
112
E-value
1.24559
5-hydroxytryptamine receptor 5A structureClick to view 3D structure5-hydroxytryptamine receptor 5AP47898HumansPredicted (SEA)
Prediction Confidence Score
0.61
Applicability Domain
1.0
Statistical Significance
1.20e-04
Supporting Reference Compounds
225
E-value
0.934191
Click to view 3D structureSodium-dependent dopamine transporterP23977Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.608
Applicability Domain
0.657
Statistical Significance
5.20e-04
Supporting Reference Compounds
203
E-value
4.04816
5-hydroxytryptamine receptor 1E structureClick to view 3D structure5-hydroxytryptamine receptor 1EP28566HumansPredicted (SEA)
Prediction Confidence Score
0.605
Applicability Domain
1.0
Statistical Significance
8.00e-05
Supporting Reference Compounds
139
E-value
0.622794
Click to view 3D structure5-hydroxytryptamine receptor 2BP30994Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.595
Applicability Domain
1.0
Statistical Significance
6.00e-05
Supporting Reference Compounds
40
E-value
0.467095
Click to view 3D structure5-hydroxytryptamine receptor 1DP79400Sus scrofaPredicted (SEA)
Prediction Confidence Score
0.571
Applicability Domain
1.0
Statistical Significance
2.00e-05
Supporting Reference Compounds
18
E-value
0.155698
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP14842Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.554
Applicability Domain
1.0
Statistical Significance
0.001
Supporting Reference Compounds
380
E-value
7.94062
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansPredicted (SEA)
Prediction Confidence Score
0.554
Applicability Domain
1.0
Statistical Significance
0.0042
Supporting Reference Compounds
1103
E-value
32.8524
Click to view 3D structure5-hydroxytryptamine receptor 2AP35363Mus musculusPredicted (SEA)
Prediction Confidence Score
0.551
Applicability Domain
1.0
Statistical Significance
6.00e-05
Supporting Reference Compounds
47
E-value
0.467095
5-hydroxytryptamine receptor 4 structureClick to view 3D structure5-hydroxytryptamine receptor 4Q13639HumansPredicted (SEA)
Prediction Confidence Score
0.524
Applicability Domain
1.0
Statistical Significance
3.10e-04
Supporting Reference Compounds
101
E-value
2.41333
5-hydroxytryptamine receptor 3A structureClick to view 3D structure5-hydroxytryptamine receptor 3AP46098HumansPredicted (SEA)
Prediction Confidence Score
0.519
Applicability Domain
1.0
Statistical Significance
3.80e-04
Supporting Reference Compounds
228
E-value
2.95827
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansPredicted (SEA)
Prediction Confidence Score
0.5
Applicability Domain
1.0
Statistical Significance
0.0051
Supporting Reference Compounds
861
E-value
40.0145
Concentrations
Not Available
External Links
DrugBank IDDB08839
HMDB IDHMDB0000259
FooDB IDFDB012158
Phenol Explorer IDNot Available
KNApSAcK IDC00001429
BiGG IDNot Available
BioCyc IDSEROTONIN
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkSerotonin
Chemspider ID5013
ChEBI ID28790
PubChem Compound ID5202
Kegg Compound IDC00780
YMDB IDNot Available
ECMDB IDM2MDB004612
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available