Doxazosin (CED0003802)

Doxazosin is an organic compound with the formula C23H25N5O5 and an average molecular weight of 451.48 g/mol. Doxazosin belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is recorded as being found in or released from 36 sources, including healthcare, pharmaceuticals, and veterinary products such as antihypertensives and drugs used in benign prostatic hypertrophy. Other sources include food preservation and fermentation processes for beer, building and construction materials like floors, ceilings, tents or canopies, and household cleaning and consumer products such as tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, cigar cigarettes, and other smoking requisites. Additionally, it is associated with electrical and electronic equipment, including antennas, amplifiers, auxiliary devices, cores yokes or armatures, and conductors or conductive bodies characterised by the conductive materials. The recorded exposure route for this compound is oral. Doxazosin acts on six recorded protein targets, serving as an antagonist/inhibitor of the Alpha-1A adrenergic receptor (ADRA1A), the Alpha-1D adrenergic receptor (ADRA1D), the voltage-gated inwardly rectifying potassium channel KCNH2, the voltage-gated inwardly rectifying potassium channel KCNH6, and two other proteins. In terms of health effects, it is used as a treatment for pheochromocytoma (PMC10074227).