Trimethoprim (CED0001063)

Trimethoprim is an organic compound with the formula C14H18N4O3 and an average molecular weight of 290.32 g/mol. Trimethoprim belongs to the anisoles, a subclass of phenol ethers within the organic compounds. Biologically, it functions as an antibacterial agent (PMC5785760) and an inhibitor (PMC5350610). It serves as a treatment for pneumonia (PMC10922816). The compound acts as an inhibitor or modulator of the protein targets Dihydrofolate reductase (folA) and Dihydrofolate reductase (DHFR). Trimethoprim is found in or released from 33 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as antibiotics, drugs for the treatment of tuberculosis, and sulfonamides and trimethoprim. It is also associated with food, food processing, and cookware, specifically the processing of meats and the preparation of malt, vinegar, wine, or sparkling wine, as well as food preservation. Other sources include drinking water, indoor air, and household cleaning and consumer products, including bleaching agents, ash trays, cigar cigarettes, other smoking requisites, and non-electric simulated smoking devices. Additionally, it is found in electrical and electronic equipment, such as electric switches, amplifiers, antennas, coils, and conductors or conductive bodies characterised by the conductive materials. Recorded exposure routes for the compound include oral, intravenous, ophthalmic, and inhalation.