Antibiotic G 418 (CED0013478)

Record Information

Version

1.0

Creation Date

2026-03-31 20:19:58 UTC

Update Date

2026-05-14 18:07:12 UTC

SynCED ID

CED0013478

Secondary Accession Numbers

CHEM057747

Identification

Common Name

Antibiotic G 418

Class

Small Molecule

Description

Antibiotic G 418 is an organic compound with the formula C20H40N4O10 and an average molecular weight of 496.56 g/mol. Antibiotic G 418 belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. This compound is found in or released from three recorded sources: healthcare, pharmaceuticals & veterinary products (antibiotics), electrical & electronic equipment (antennas), and food, food processing & cookware (preparation of wine or sparkling wine). Recorded exposure routes include inhalation and oral intake. In terms of biological activity, Antibiotic G 418 acts as an inhibitor of the protein target ornithine decarboxylase (ODC1).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₀H₄₀N₄O₁₀

Average Molecular Mass

496.558 g/mol

Monoisotopic Mass

496.274 g/mol

CAS Registry Number

49863-47-0;49662-03-5;83855-92-9

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

InChI Identifier

InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+/m1/s1

InChI Key

BRZYSWJRSDMWLG-DJWUNRQOSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

antimicrobial agent (PMC10506223 , PMC3871212 )?
aminoglycoside antibiotic (PMC7080118 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00ds-0209800000-130d98a9e57f5bae0067	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03k9-0907100000-38b22162102e5d940e4c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00ds-5904000000-c6101399452260e17172	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014i-2911100000-e163421a53270b604405	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0l2s-3928500000-c4e3efbf8c2cb4f4a102	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-3691000000-6f17dbad85894539e728	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
8852.0 Log mg/kg [5000:16000]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
Usher syndrome	Has Therapeutic Effect On	Not Available	Not Available	PMC5818290
mucopolysaccharidosis I	Has Therapeutic Effect On	Not Available	Not Available	PMC5818290

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000306	Antibiotics?Antibiotics are synthetic or semi-synthetic compounds used to treat bacterial infections in humans and animals.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000544	Fermentation Processes For Beer?Fermentation processes for beer involve the conversion of sugars into alcohol and carbon dioxide by yeast.	Food, food processing & cookware	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000549	Preparation Of Wine Or Sparkling Wine?The preparation of wine or sparkling wine involves various stages, including fermentation, aging, and bottling, which can introduce potential sources of synthetic chemical contamination.	Food, food processing & cookware	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Gap junction beta-2 protein	P29033	Humans	Predicted (SEA)	Prediction Confidence Score 0.285 Applicability Domain 0.304 Statistical Significance 1.20e-04 Supporting Reference Compounds 2 E-value 0.934191
Click to view 3D structure	Human immunodeficiency virus type 1 REV	Q77Y21	Human immunodeficiency virus 1	Predicted (SEA)	Prediction Confidence Score 0.281 Applicability Domain 0.314 Statistical Significance 9.00e-05 Supporting Reference Compounds 4 E-value 0.700643
Click to view 3D structure	Gap junction alpha-1 protein	P17302	Humans	Predicted (SEA)	Prediction Confidence Score 0.274 Applicability Domain 0.274 Low confidence Statistical Significance 1.20e-04 Supporting Reference Compounds 1 E-value 0.934191
Click to view 3D structure	Beta-ketoacyl-[acyl-carrier-protein] synthase III	P0A6R0	Escherichia coli (strain K12)	Predicted (SEA)	Prediction Confidence Score 0.24 Applicability Domain 0.358 Statistical Significance 1.10e-04 Supporting Reference Compounds 3 E-value 0.856341
Click to view 3D structure	Aminoglycoside acetyltransferase	Q70E71	Enterococcus durans	Predicted (SEA)	Prediction Confidence Score 0.212 Applicability Domain 0.212 Low confidence Statistical Significance 0.0037 Supporting Reference Compounds 1 E-value 28.8042
Click to view 3D structure	3-oxoacyl-[acyl-carrier-protein] synthase 3	C3TDZ2	Escherichia coli	Predicted (SEA)	Prediction Confidence Score 0.211 Applicability Domain 0.358 Statistical Significance 1.70e-04 Supporting Reference Compounds 2 E-value 1.32344
Click to view 3D structure	Heparanase	Q9Y251	Humans	Predicted (SEA)	Prediction Confidence Score 0.183 Applicability Domain 0.296 Low confidence Statistical Significance 0.0068 Supporting Reference Compounds 11 E-value 53.2489
Click to view 3D structure	E-selectin	P98105	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.17 Applicability Domain 0.17 Low confidence Statistical Significance 0.0014 Supporting Reference Compounds 1 E-value 11.0546
Click to view 3D structure	DNA topoisomerase 2-alpha	P11388	Humans	Predicted (SEA)	Prediction Confidence Score 0.169 Applicability Domain 0.194 Low confidence Statistical Significance 0.2331 Supporting Reference Compounds 27 E-value 1814.82
Click to view 3D structure	Endopolygalactyuronase	P79074	Chondrostereum purpureum	Predicted (SEA)	Prediction Confidence Score 0.165 Applicability Domain 0.165 Low confidence Statistical Significance 8.80e-04 Supporting Reference Compounds 1 E-value 6.85073
Click to view 3D structure	Protein Tat	P04326	Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)(HIV-1)	Predicted (SEA)	Prediction Confidence Score 0.164 Applicability Domain 0.245 Low confidence Statistical Significance 0.0013 Supporting Reference Compounds 2 E-value 10.5096
Click to view 3D structure	Sialic acid-binding Ig-like lectin 7	Q9Y286	Humans	Predicted (SEA)	Prediction Confidence Score 0.162 Applicability Domain 0.162 Low confidence Statistical Significance 0.0012 Supporting Reference Compounds 1 E-value 9.41976
Click to view 3D structure	Streptokinase A	P10520	Streptococcus pyogenes serotype M1	Predicted (SEA)	Prediction Confidence Score 0.159 Applicability Domain 0.167 Low confidence Statistical Significance 0.9599 Supporting Reference Compounds 425 E-value 7472.44
Click to view 3D structure	Chitin synthase 1	P08004	Saccharomyces cerevisiae S288c	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.158 Low confidence Statistical Significance 0.0043 Supporting Reference Compounds 2 E-value 33.6309
Click to view 3D structure	Transient receptor potential cation channel subfamily V member 1	Q8NER1	Humans	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.314 Statistical Significance 0.913 Supporting Reference Compounds 104 E-value 7107.95
Click to view 3D structure	CD44 antigen	P16070	Humans	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.153 Low confidence Statistical Significance 0.0054 Supporting Reference Compounds 1 E-value 42.4278
Click to view 3D structure	CD44 antigen	P15379	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.153 Low confidence Statistical Significance 0.0054 Supporting Reference Compounds 1 E-value 42.4278
Click to view 3D structure	Neuraminidase	B4URF0	Influenza A virus	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.169 Low confidence Statistical Significance 0.3594 Supporting Reference Compounds 42 E-value 2798.06
Click to view 3D structure	Motilin receptor	A5A4K8	Oryctolagus cuniculus	Predicted (SEA)	Prediction Confidence Score 0.151 Applicability Domain 0.185 Low confidence Statistical Significance 0.001 Supporting Reference Compounds 5 E-value 8.17417
Click to view 3D structure	ATP synthase subunit beta, mitochondrial	P00830	Saccharomyces cerevisiae S288c	Predicted (SEA)	Prediction Confidence Score 0.151 Applicability Domain 0.151 Low confidence Statistical Significance 0.0013 Supporting Reference Compounds 1 E-value 10.0426
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	Prediction Confidence Score 0.15 Applicability Domain 0.167 Low confidence Statistical Significance 0.9977 Supporting Reference Compounds 1538 E-value 7767.33
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.15 Applicability Domain 0.185 Low confidence Statistical Significance 0.9964 Supporting Reference Compounds 1498 E-value 7757.13
Click to view 3D structure	Neuraminidase	Q3S340	Influenza B virus	Predicted (SEA)	Prediction Confidence Score 0.149 Applicability Domain 0.169 Low confidence Statistical Significance 0.0033 Supporting Reference Compounds 4 E-value 25.3788
Click to view 3D structure	Fibroblast growth factor 1	P05230	Humans	Predicted (SEA)	Prediction Confidence Score 0.148 Applicability Domain 0.151 Low confidence Statistical Significance 0.0027 Supporting Reference Compounds 6 E-value 21.175
Click to view 3D structure	ATP-dependent translocase ABCB1	P08183	Humans	Predicted (SEA)	Prediction Confidence Score 0.148 Applicability Domain 0.167 Low confidence Statistical Significance 0.9535 Supporting Reference Compounds 139 E-value 7423.16