Remimazolam (CED0006369)

Record Information
Version1.0
Creation Date2026-04-05 11:51:17 UTC
Update Date2026-05-14 19:21:11 UTC
Accession NumberCHEM100651
Identification
Common NameRemimazolam
ClassSmall Molecule
Description
Remimazolam is an organic compound with the chemical formula C21H19BrN4O2 and an average molecular weight of 439.31 g/mol. Remimazolam belongs to the 1,4-benzodiazepines, a subclass of benzodiazepines within the organic compounds. Within the broader chemical hierarchy, it is classified as an organoheterocyclic compound. This compound is utilized in healthcare, pharmaceuticals, and veterinary products as a hypnotic and sedative, with intravenous administration as the recorded route of exposure. Remimazolam acts upon 16 recorded protein targets. Specifically, it serves as an agonist and positive allosteric modulator of the Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5), and Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3), in addition to 12 other proteins.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC21H19BrN4O2
Average Molecular Mass439.313 g/mol
Monoisotopic Mass438.069 g/mol
CAS Registry Number308242-62-8
IUPAC NameNot Available
Traditional NameNot Available
SMILES[H][C@@]1(CCC(=O)OC)N=C(C2=CC=CC=N2)C2=C(C=CC(Br)=C2)N2C(C)=CN=C12
InChI IdentifierInChI=1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1
InChI KeyCYHWMBVXXDIZNZ-KRWDZBQOSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-052r-0001900000-b57e243ae97cb653ff1cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-06ri-0009800000-ddb85611c97b91035cc8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ufr-3029000000-a4ce8006478b468bc44bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0000900000-effef76a695f35a72188Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-052r-2002900000-92cd3bb2e0922096cf00Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9004200000-cec544c7489effc39b68Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0000900000-9e786e3b8baf00a2740aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0001900000-d860ed73bba0e51bbba6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0fbi-1009100000-b2eab18c8679d38f69e7Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0000900000-63d4bb323807fcc4be03Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ufr-1009400000-be154ebc85550fd77643Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9015000000-c6d09852cb56f49e09f2Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
963.0Log mg/kg[540:1700]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
376Hypnotics and sedativesHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
2 pathways
Remimazolam Action Pathway
Remimazolam Action Pathway
Remimazolam Drug Metabolism Action Pathway
Remimazolam Drug Metabolism Action Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Mediator of RNA polymerase II transcription subunit 1 structureClick to view 3D structureMediator of RNA polymerase II transcription subunit 1Q15648HumansPredicted (SEA)4.12601
Beta/gamma crystallin domain-containing protein 1 structureClick to view 3D structureBeta/gamma crystallin domain-containing protein 1Q9Y4K1HumansPredicted (SEA)4.12601
Click to view 3D structureHornerinQ86YZ3HumansPredicted (SEA)4.12601
Nuclear factor related to kappa-B-binding protein structureClick to view 3D structureNuclear factor related to kappa-B-binding proteinQ6P4R8HumansPredicted (SEA)4.12601
Cell division cycle-associated protein 2 structureClick to view 3D structureCell division cycle-associated protein 2Q69YH5HumansPredicted (SEA)4.12601
Lymphoid-specific helicase structureClick to view 3D structureLymphoid-specific helicaseQ9NRZ9HumansPredicted (SEA)4.12601
Pre-mRNA 3'-end-processing factor FIP1 structureClick to view 3D structurePre-mRNA 3'-end-processing factor FIP1Q6UN15HumansPredicted (SEA)4.12601
Protein FRG1 structureClick to view 3D structureProtein FRG1Q14331HumansPredicted (SEA)4.12601
Click to view 3D structureArginine and glutamate-rich protein 1Q9NWB6HumansPredicted (SEA)4.12601
Click to view 3D structureG patch domain-containing protein 8Q9UKJ3HumansPredicted (SEA)4.12601
Click to view 3D structureHIRA-interacting protein 3Q9BW71HumansPredicted (SEA)4.12601
Click to view 3D structureBolA-like protein 2Q9H3K6HumansPredicted (SEA)4.12601
Protein SET structureClick to view 3D structureProtein SETQ01105HumansPredicted (SEA)4.12601
Click to view 3D structureCoilinP38432HumansPredicted (SEA)4.12601
Plastin-2 structureClick to view 3D structurePlastin-2P13796HumansPredicted (SEA)4.12601
DNA dC->dU-editing enzyme APOBEC-3C structureClick to view 3D structureDNA dC->dU-editing enzyme APOBEC-3CQ9NRW3HumansPredicted (SEA)4.12601
Histone H2A type 1-D structureClick to view 3D structureHistone H2A type 1-DP20671HumansPredicted (SEA)4.12601
U4/U6 small nuclear ribonucleoprotein Prp31 structureClick to view 3D structureU4/U6 small nuclear ribonucleoprotein Prp31Q8WWY3HumansPredicted (SEA)4.12601
Click to view 3D structureSAP30-binding proteinQ9UHR5HumansPredicted (SEA)4.12601
CD59 glycoprotein structureClick to view 3D structureCD59 glycoproteinP13987HumansPredicted (SEA)4.12601
Splicing factor 3B subunit 4 structureClick to view 3D structureSplicing factor 3B subunit 4Q15427HumansPredicted (SEA)4.12601
Splicing factor 3A subunit 2 structureClick to view 3D structureSplicing factor 3A subunit 2Q15428HumansPredicted (SEA)4.12601
mRNA-capping enzyme structureClick to view 3D structuremRNA-capping enzymeO60942HumansPredicted (SEA)4.12601
GDP-mannose 4,6 dehydratase structureClick to view 3D structureGDP-mannose 4,6 dehydrataseO60547HumansPredicted (SEA)4.12601
Nitric oxide synthase-interacting protein structureClick to view 3D structureNitric oxide synthase-interacting proteinQ9Y314HumansPredicted (SEA)4.12601
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available