Plazomicin (CED0007823)

Record Information
Version1.0
Creation Date2026-04-05 13:47:51 UTC
Update Date2026-08-22 05:38:19 UTC
Accession NumberCHEM103219
Identification
Common NamePlazomicin
ClassSmall Molecule
Description
Plazomicin is an organic compound with the chemical formula C25H48N6O10. Plazomicin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 592.69 g/mol, Plazomicin is a heavy molecule. This compound is found in healthcare, pharmaceuticals, and veterinary products as an aminoglycoside antibacterial, with intravenous administration as a recorded exposure route. Plazomicin acts on two recorded protein targets, functioning as an inhibitor of the mitochondrial rRNA methyltransferase 2 (MRM2) and the small ribosomal subunit protein uS14 (rpsN).
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC25H48N6O10
Average Molecular Mass592.691 g/mol
Monoisotopic Mass592.343 g/mol
CAS Registry Number1154757-24-0
IUPAC NameNot Available
Traditional NameNot Available
SMILESCN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@H]3OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC(=O)[C@@H](O)CCN)OC[C@]1(C)O
InChI IdentifierInChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1
InChI KeyIYDYFVUFSPQPPV-PEXOCOHZSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00nf-0102950000-9d44430ad4754eb64027Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03yi-1252910000-27f3c56e04fa89772c91Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00lr-7749300000-cf3b4bf038d03cb68e1bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-1900110000-e3ae98a7e5df5ac3bdc9Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-02gc-9201420000-25f7b94a94d3fdaeea5cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-5529100000-2bddb0ee60add1cd9024Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
6527.0Log mg/kg[3700:12000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
344Aminoglycoside antibacterialsHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
3 pathways
Plazomicin Action Pathway
Plazomicin Action Pathway
Plazomicin Drug Metabolism Action Pathway
Plazomicin Drug Metabolism Action Pathway
Plazomicin Predicted Metabolism Pathway
Plazomicin Predicted Metabolism Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Gap junction alpha-1 protein structureClick to view 3D structureGap junction alpha-1 proteinP17302HumansPredicted (SEA)5.3716
Gap junction beta-2 protein structureClick to view 3D structureGap junction beta-2 proteinP29033HumansPredicted (SEA)5.52729
Click to view 3D structureHuman immunodeficiency virus type 1 REVQ77Y21Human immunodeficiency virus 1Predicted (SEA)2.25763
Asialoglycoprotein receptor 1 structureClick to view 3D structureAsialoglycoprotein receptor 1P07306HumansPredicted (SEA)15.8034
Click to view 3D structureAminoglycoside acetyltransferaseQ70E71Enterococcus duransPredicted (SEA)50.5241
Click to view 3D structureNeuraminidaseB4URF0Influenza A virusPredicted (SEA)1057.19
Beta-ketoacyl-[acyl-carrier-protein] synthase III structureClick to view 3D structureBeta-ketoacyl-[acyl-carrier-protein] synthase IIIP0A6R0Escherichia coli (strain K12)Predicted (SEA)6.85073
Click to view 3D structureNeuraminidaseP03468Influenza A virus (A/Puerto Rico/8/1934(H1N1))Predicted (SEA)1243.25
Click to view 3D structureNeuraminidaseP03471Influenza A virus (A/Memphis/1/1971(H3N2))Predicted (SEA)506.02
Click to view 3D structureNeuraminidaseA5Z252Influenza A virusPredicted (SEA)931.544
Click to view 3D structureCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1P54751Mus musculusPredicted (SEA)20.1629
Click to view 3D structureNeuraminidaseQ75VQ4Influenza A virus (A/Aichi/2/1968(H3N2))Predicted (SEA)48.4222
Neuraminidase structureClick to view 3D structureNeuraminidaseP03474Influenza B virus (strain B/Lee/1940)Predicted (SEA)269.903
Click to view 3D structureNeuraminidaseQ07599Influenza A virus (strain A/Duck/Ukraine/1/1963 H3N8)Predicted (SEA)572.737
Click to view 3D structureN-acetyllactosaminide alpha-1,3-galactosyltransferaseP50127Sus scrofaPredicted (SEA)148.225
Click to view 3D structurePutative beta-hexosaminidaseQ9RK76Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Predicted (SEA)294.036
Click to view 3D structureNeuraminidaseQ2LFS1Influenza A virusPredicted (SEA)695.583
Click to view 3D structureNeuraminidaseQ6Q793Influenza A virusPredicted (SEA)62.2794
Click to view 3D structureNeuraminidaseQ6XV28Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)Predicted (SEA)202.408
Click to view 3D structureGag-Pol polyproteinQ7ZJM1Human immunodeficiency virus 1Predicted (SEA)3876.11
Click to view 3D structureHemagglutinin-neuraminidaseQ06992Human parainfluenza virus 1Predicted (SEA)15.6477
Click to view 3D structureNeuraminidaseC4LRQ6Influenza A virusPredicted (SEA)279.712
DIS3-like exonuclease 2 structureClick to view 3D structureDIS3-like exonuclease 2Q8IYB7HumansPredicted (SEA)9.809
Click to view 3D structureMyelin-associated glycoproteinP20916HumansPredicted (SEA)52.8596
Click to view 3D structureNeuraminidaseP03469Influenza A virus (strain A/USSR/90/1977 H1N1)Predicted (SEA)1095.42
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available