Eravacycline (CED0006492)

Record Information

Version

1.0

Creation Date

2026-04-05 13:48:36 UTC

Update Date

2026-08-22 07:29:23 UTC

Accession Number

CHEM103239

Identification

Common Name

Eravacycline

Class

Small Molecule

Description

Eravacycline belongs to the tetracyclines, a class of phenylpropanoids and polyketides within the organic compounds. With an average molecular weight of 558.56 g/mol, Eravacycline is a heavy molecule. It has the chemical formula C27H31FN4O8. This compound is found in healthcare, pharmaceuticals, and veterinary products, and is administered through intravenous exposure. In terms of its biological activity, Eravacycline acts as an inhibitor of the small ribosomal subunit protein uS4 (rpsD).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₇H₃₁FN₄O₈

Average Molecular Mass

558.563 g/mol

Monoisotopic Mass

558.213 g/mol

CAS Registry Number

1207283-85-9

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

[H][C@@]12CC3=C(C(O)=C(NC(=O)CN4CCCC4)C=C3F)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2

InChI Identifier

InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1

InChI Key

HLFSMUUOKPBTSM-ISIOAQNYSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-9000120000-45cce15d4c781ab74e87	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-9000100000-83c0a552a776820c56dc	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-053r-9000000000-945fe031df3a43c48dbd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-0100290000-4ac0d2d1546d1a2b7117	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-2300890000-edc42c34e1102da3974b	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-052f-9106200000-b7922199feb6f9ab4865	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
1128.0	Log mg/kg	[630:2000]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
338	Tetracyclines	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

1 pathway

Eravacycline Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Multidrug transporter MdfA	P0AEY8	Escherichia coli K-12	Predicted (SEA)	0.622794
Click to view 3D structure	Streptokinase A	P10520	Streptococcus pyogenes serotype M1	Predicted (SEA)	372.82
Click to view 3D structure	Protein Tat	P04608	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1)	Predicted (SEA)	347.83
Click to view 3D structure	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	Humans	Predicted (SEA)	1595.21
Click to view 3D structure	Mitogen-activated protein kinase kinase kinase kinase 1	P70218	Mus musculus	Predicted (SEA)	70.3757
Click to view 3D structure	P2Y purinoceptor 12	Q9H244	Humans	Predicted (SEA)	250.363
Click to view 3D structure	Vascular endothelial growth factor receptor 2	P35968	Humans	Predicted (SEA)	6187.77
Click to view 3D structure	Tyrosine-protein phosphatase non-receptor type 7	P35236	Humans	Predicted (SEA)	1751.14
Click to view 3D structure	Platelet-derived growth factor receptor beta	P09619	Humans	Predicted (SEA)	5262.37
Click to view 3D structure	Epidermal growth factor receptor	P00533	Humans	Predicted (SEA)	6556.85
Click to view 3D structure	N-formyl peptide receptor 2	P25090	Humans	Predicted (SEA)	638.986
Click to view 3D structure	Mast/stem cell growth factor receptor Kit	P10721	Humans	Predicted (SEA)	6008.56
Click to view 3D structure	ATPase family AAA domain-containing protein 2	Q6PL18	Humans	Predicted (SEA)	266.322
Click to view 3D structure	Platelet-derived growth factor receptor alpha	P16234	Humans	Predicted (SEA)	5492.96
Click to view 3D structure	Insulin-like growth factor 1 receptor	P08069	Humans	Predicted (SEA)	6140.12
Click to view 3D structure	Receptor-type tyrosine-protein kinase FLT3	P36888	Humans	Predicted (SEA)	6627.85
Click to view 3D structure	Macrophage colony-stimulating factor 1 receptor	P07333	Humans	Predicted (SEA)	6274.88
Click to view 3D structure	Mitogen-activated protein kinase 14	Q16539	Humans	Predicted (SEA)	6215.95
Click to view 3D structure	Tyrosine-protein kinase JAK3	P52333	Humans	Predicted (SEA)	6461.1
Click to view 3D structure	Tyrosine-protein kinase Lck	P06239	Humans	Predicted (SEA)	6758.32
Click to view 3D structure	Tyrosine-protein kinase JAK2	O60674	Humans	Predicted (SEA)	6637.27
Click to view 3D structure	Tyrosine-protein kinase ITK/TSK	Q08881	Humans	Predicted (SEA)	5933.28
Click to view 3D structure	Glycogen synthase kinase-3 beta	P49841	Humans	Predicted (SEA)	6824.5
Click to view 3D structure	Tyrosine-protein kinase BTK	Q06187	Humans	Predicted (SEA)	6306.72
Click to view 3D structure	Vascular endothelial growth factor receptor 1	P17948	Humans	Predicted (SEA)	6250.67