Talazoparib (CED0003950)

Record Information

Version

1.0

Creation Date

2026-04-05 13:49:57 UTC

Update Date

2026-08-20 01:52:57 UTC

Accession Number

CHEM103276

Identification

Common Name

Talazoparib

Class

Small Molecule

Description

Talazoparib is an organic compound with the chemical formula C19H14F2N6O and an average molecular weight of 380.36 g/mol. Talazoparib belongs to the phenylquinolines, a subclass of quinolines and derivatives within the organic compounds. This compound is used as an antineoplastic agent within the sector of healthcare, pharmaceuticals, and veterinary products, with oral administration as the recorded exposure route. In terms of biological activity, talazoparib acts as an inhibitor of two protein targets: Poly [ADP-ribose] polymerase 1 (PARP1) and Poly [ADP-ribose] polymerase 2 (PARP2).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₉H₁₄F₂N₆O

Average Molecular Mass

380.359 g/mol

Monoisotopic Mass

380.120 g/mol

CAS Registry Number

1207456-01-6

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CN1N=CN=C1[C@@H]1[C@H](NC2=C3C1=NNC(=O)C3=CC(F)=C2)C1=CC=C(F)C=C1

InChI Identifier

InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1

InChI Key

HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0009000000-8890391d08556ebcc3a2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0gwr-0139000000-6078adfa1944202b3917	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-1390000000-882ff142473d58037e79	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0009000000-e8b89e1c1fb10a661490	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01t9-0009000000-22226a9fcac2f1f87897	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-1059000000-4fb727c8e378ffa28239	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
589.0	Log mg/kg	[330:1000]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
358	Antineoplastic agents	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

2 pathways

Talazoparib Drug Metabolism

Talazoparib Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Poly [ADP-ribose] polymerase 1	P09874	Humans	Predicted (SEA)	23.9776
Click to view 3D structure	Poly [ADP-ribose] polymerase tankyrase-1	O95271	Humans	Predicted (SEA)	15.8812
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	Humans	Predicted (SEA)	6.85073
Click to view 3D structure	Poly [ADP-ribose] polymerase 2	Q9UGN5	Humans	Predicted (SEA)	18.1389
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP12	Q9H0J9	Humans	Predicted (SEA)	6.85073
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	Humans	Predicted (SEA)	8.64126
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP11	Q9NR21	Humans	Predicted (SEA)	3.65891
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP8	Q8N3A8	Humans	Predicted (SEA)	0.700643
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP16	Q8N5Y8	Humans	Predicted (SEA)	1.24559
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	Humans	Predicted (SEA)	6.61718
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP4	Q9UKK3	Humans	Predicted (SEA)	1.79053
Click to view 3D structure	ALK tyrosine kinase receptor	Q9UM73	Humans	Predicted (SEA)	4687.46
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	6633.22
Click to view 3D structure	Tyrosine-protein kinase JAK2	O60674	Humans	Predicted (SEA)	5454.27
Click to view 3D structure	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	Humans	Predicted (SEA)	814.536
Click to view 3D structure	Aurora kinase B	Q96GD4	Humans	Predicted (SEA)	5581.09
Click to view 3D structure	High affinity nerve growth factor receptor	P04629	Humans	Predicted (SEA)	5499.66
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	5276.93
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	5376.42
Click to view 3D structure	Tyrosine-protein kinase JAK3	P52333	Humans	Predicted (SEA)	5765.44
Click to view 3D structure	Ubiquitin carboxyl-terminal hydrolase 13	Q92995	Humans	Predicted (SEA)	110.779
Click to view 3D structure	Casein kinase I isoform alpha	P48729	Humans	Predicted (SEA)	5389.35
Click to view 3D structure	Glycogen synthase kinase-3 beta	P49841	Humans	Predicted (SEA)	6205.44
Click to view 3D structure	Serine/threonine-protein kinase pim-1	P11309	Humans	Predicted (SEA)	5907.43
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	5466.96