2-{[5-(3-Chlorophenyl)-3-hydroxypyridin-2-yl]formamido}acetic acid (CED0129215)

Record Information
Version1.0
Creation Date2026-04-05 14:01:23 UTC
Update Date2026-08-19 04:22:15 UTC
Accession NumberCHEM103535
Identification
Common Name2-{[5-(3-Chlorophenyl)-3-hydroxypyridin-2-yl]formamido}acetic acid
ClassSmall Molecule
Description
2-{[5-(3-Chlorophenyl)-3-hydroxypyridin-2-yl]formamido}acetic acid belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. This compound has the chemical formula $\text{C}_{14}\text{H}_{11}\text{ClN}_2\text{O}_4$ and an average molecular weight of 306.70 g/mol. In terms of its biological activity, the compound acts upon five recorded protein targets. It functions as an inhibitor or stabilization agent for Prolyl hydroxylase EGLN2, Prolyl hydroxylase EGLN3, Egl nine homolog 1 (EGLN1), and Hypoxia-inducible factor 1-alpha (HIF1A), in addition to one other protein. Regarding its application and occurrence, it is found in or released from one recorded source: healthcare, pharmaceuticals, and veterinary products, specifically within antianemic preparations. The recorded route of exposure for this compound is oral.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC14H11ClN2O4
Average Molecular Mass306.700 g/mol
Monoisotopic Mass306.041 g/mol
CAS Registry Number1000025-07-9
IUPAC NameNot Available
Traditional NameNot Available
SMILESOC(=O)CNC(=O)C1=C(O)C=C(C=N1)C1=CC(Cl)=CC=C1
InChI IdentifierInChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
InChI KeyJGRXMPYUTJLTKT-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-001i-1090000000-9f4910edaee2dfdf5001Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ab9-9046000000-ebeb9b204a86817cb172Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00fr-9010000000-ffd74398c3603baa5a22Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00b9-9000000000-006757e26c1770b6e627Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-1079000000-5cfe47c9589766f97a0cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ir0-7792000000-0e0cc7a9802a17831d80Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0w90-9640000000-7139bc30310951f08313Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
2395.0Log mg/kg[1300:4300]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
276Antianemic preparationsHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Egl nine homolog 1 structureClick to view 3D structureEgl nine homolog 1Q9GZT9HumansPredicted (SEA)0.155698
Click to view 3D structureProlyl hydroxylase EGLN3Q9H6Z9HumansPredicted (SEA)0.155698
Vascular endothelial growth factor receptor 1 structureClick to view 3D structureVascular endothelial growth factor receptor 1P17948HumansPredicted (SEA)1.86838
Vascular endothelial growth factor A, long form structureClick to view 3D structureVascular endothelial growth factor A, long formP15692HumansPredicted (SEA)0.0778492
Click to view 3D structureProlyl 4-hydroxylaseQ84406Paramecium bursaria Chlorella virus 1Predicted (SEA)0.0778492
Gamma-butyrobetaine dioxygenase structureClick to view 3D structureGamma-butyrobetaine dioxygenaseO75936HumansPredicted (SEA)0.544945
Aspartyl/asparaginyl beta-hydroxylase structureClick to view 3D structureAspartyl/asparaginyl beta-hydroxylaseQ12797HumansPredicted (SEA)0.856341
Methylcytosine dioxygenase TET2 structureClick to view 3D structureMethylcytosine dioxygenase TET2Q6N021HumansPredicted (SEA)0.0778492
Methylcytosine dioxygenase TET3 structureClick to view 3D structureMethylcytosine dioxygenase TET3O43151HumansPredicted (SEA)0.0778492
Bifunctional peptidase and arginyl-hydroxylase JMJD5 structureClick to view 3D structureBifunctional peptidase and arginyl-hydroxylase JMJD5Q8N371HumansPredicted (SEA)0.233548
Methylcytosine dioxygenase TET1 structureClick to view 3D structureMethylcytosine dioxygenase TET1Q8NFU7HumansPredicted (SEA)4.20386
Prolyl 3-hydroxylase OGFOD1 structureClick to view 3D structureProlyl 3-hydroxylase OGFOD1Q8N543HumansPredicted (SEA)0.0778492
Click to view 3D structureMembrane metallo-endopeptidase-like 1Q495T6HumansPredicted (SEA)2.88042
Click to view 3D structure15-cis-phytoene desaturaseP26294Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)Predicted (SEA)5.60514
Click to view 3D structureGamma-butyrobetaine dioxygenaseP80193Pseudomonas sp. (strain AK-1)Predicted (SEA)1.79053
Click to view 3D structure2-oxoglutarate receptor 1Q96P68HumansPredicted (SEA)2.88042
Alpha-ketoglutarate-dependent dioxygenase FTO structureClick to view 3D structureAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1HumansPredicted (SEA)9.73115
Click to view 3D structureEgl nine homolog 1P59722Rattus norvegicusPredicted (SEA)1.01204
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)698.852
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)949.605
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)423.655
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)694.571
Tyrosine-protein kinase JAK2 structureClick to view 3D structureTyrosine-protein kinase JAK2O60674HumansPredicted (SEA)877.127
Epidermal growth factor receptor structureClick to view 3D structureEpidermal growth factor receptorP00533HumansPredicted (SEA)1040.14
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)571.647
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available