Cariprazine (CED0006554)

Record Information

Version

1.0

Creation Date

2026-04-14 15:57:53 UTC

Update Date

2026-05-14 18:17:27 UTC

Accession Number

CHEM129643

Identification

Common Name

Cariprazine

Class

Small Molecule

Description

Cariprazine is an organic compound with the chemical formula C21H32Cl2N4O and an average molecular weight of 427.41 g/mol. Cariprazine belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is classified as an organoheterocyclic compound. This compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically as an antipsychotic. The recorded route of exposure is oral. Cariprazine interacts with eight recorded protein targets. It acts as an antagonist or partial agonist of the D(2) dopamine receptor (DRD2), the D(3) dopamine receptor (DRD3), the 5-hydroxytryptamine receptor 1A (HTR1A), and the 5-hydroxytryptamine receptor 2B (HTR2B). Additionally, it targets four other proteins.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₁H₃₂Cl₂N₄O

Average Molecular Mass

427.410 g/mol

Monoisotopic Mass

426.195 g/mol

CAS Registry Number

839712-12-8

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1

InChI Identifier

InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-

InChI Key

KPWSJANDNDDRMB-QAQDUYKDSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0101900000-4026124d9978118188e3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000e-9777400000-454717801bd05733935e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-009i-9432000000-51d9b3b6a83f8e9f6cbd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-2001900000-bf877dc838c436396e70	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0059-4019600000-de04633b9753cd9481fb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0076-9210000000-22d6a3784986c94531a3	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
240.0	Log mg/kg	[130:430]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
374	Antipsychotics	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	2.33548
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	2.72472
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	0.778492
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	1.79053
Click to view 3D structure	D(4) dopamine receptor	P21917	Humans	Predicted (SEA)	0.856341
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	1.86838
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Predicted (SEA)	0.934191
Click to view 3D structure	5-hydroxytryptamine receptor 7	P34969	Humans	Predicted (SEA)	3.42537
Click to view 3D structure	D(1B) dopamine receptor	P21918	Humans	Predicted (SEA)	0.856341
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Predicted (SEA)	5.2159
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	8.56341
Click to view 3D structure	D(3) dopamine receptor	P19020	Rattus norvegicus	Predicted (SEA)	8.17417
Click to view 3D structure	D(2) dopamine receptor	P61169	Rat	Predicted (SEA)	27.7143
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	17.2825
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	15.8034
Click to view 3D structure	Alpha-1A adrenergic receptor	P35348	Humans	Predicted (SEA)	18.5281
Click to view 3D structure	D(1A) dopamine receptor	P18901	Rattus norvegicus	Predicted (SEA)	18.061
Click to view 3D structure	Alpha-1B adrenergic receptor	P35368	Humans	Predicted (SEA)	17.8275
Click to view 3D structure	5-hydroxytryptamine receptor 1B	P28222	Humans	Predicted (SEA)	16.7376
Click to view 3D structure	5-hydroxytryptamine receptor 1D	P28221	Humans	Predicted (SEA)	17.6718
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Predicted (SEA)	6.61718
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Predicted (SEA)	8.56341
Click to view 3D structure	5-hydroxytryptamine receptor 5A	P47898	Humans	Predicted (SEA)	8.09632
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	24.1333
Click to view 3D structure	Alpha-1D adrenergic receptor	P25100	Humans	Predicted (SEA)	19.7737