Sennosides (CED0006909)

Record Information
Version1.0
Creation Date2026-04-14 18:14:18 UTC
Update Date2026-08-22 14:20:51 UTC
Accession NumberCHEM131241
Identification
Common NameSennosides
ClassSmall Molecule
Description
Sennosides belongs to the anthracenecarboxylic acids and derivatives, a subclass of anthracenes within the organic compounds. With an average molecular weight of 862.75 g/mol, Sennosides is a heavy molecule. It is characterized by the chemical formula C42H38O20 and is classified within the superclass of benzenoids. The compound is identified in seven recorded sources. These include household cleaning and consumer products such as pipe accessories and non electric simulated smoking devices, as well as electrical and electronic equipment including electrodes, television systems, and electrically stimulated smoking devices. Additionally, it is found in food preservation within the category of food, food processing and cookware, and is used in healthcare, pharmaceuticals and veterinary products as drugs for constipation. The recorded route of exposure for this compound is oral. At the molecular level, sennosides interact with two recorded protein targets. It acts as an inhibitor of Aquaporin-3 (AQP3) and Reverse transcriptase/RNaseH (pol).
Contaminant TypeNot Available
Chemical Structure
SynonymsNot Available
Chemical FormulaC42H38O20
Average Molecular Mass862.746 g/mol
Monoisotopic Mass862.196 g/mol
CAS Registry Number517-43-1
IUPAC NameNot Available
Traditional NameNot Available
SMILESOCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O
InChI IdentifierInChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)
InChI KeyIPQVTOJGNYVQEO-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
LC-MS/MSLC-MS/MS Spectrumsplash10-01p2-0014029240-8eed51bf761ee5079e67Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00dr-0094301000-9718c831fa5649005ec1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000000090-1bd0b04b288d1e20d03fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0002001090-398271be6a426293523dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000001090-49ea15825f17aa180b7cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000000090-846387142135e14b55e2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000j-0017019240-266a766689f646fbefc0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0002001090-890251e147c278df1db1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000000090-da7e40a3ab3703a0b7c2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00dr-0094400000-3b49f357e910e1f381e5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000000090-dae796a53c1c97327fe9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0002000090-d7d363dbfaf0ba3dc104Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0001000090-69b3fd6f2c364bcc1097Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000i-0049218040-6a39c7ee08b0e2ffee74Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01p2-0016119370-9a1e7760edc61797ab5dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00dr-0094400000-d28c812b8c463c505e54Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity ValuesNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
253Drugs for constipationHealthcare, pharmaceuticals & veterinary productsNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
519ElectrodesElectrical & Electronic EquipmentNot Available
537Television SystemsElectrical & Electronic EquipmentNot Available
545Food PreservationFood, food processing & cookwareNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
562Pipe AccessoriesHousehold cleaning & consumer productsNot Available
580Manufacture Preparation Of Tobacco ProductsIndustrial manufacturing & chemical processingNot Available
611Anti Perspirants Or Body DeoderantsPersonal care & cosmeticsNot Available
615Eye Makeup ProductsPersonal care & cosmeticsNot Available
617Lip Care ProductsPersonal care & cosmeticsNot Available
618Lip Makeup ProductsPersonal care & cosmeticsNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureHexokinase HKDC1Q2TB90HumansPredicted (SEA)0.778492
Carbonic anhydrase 12 structureClick to view 3D structureCarbonic anhydrase 12O43570HumansPredicted (SEA)67.7288
Click to view 3D structureZinc finger protein mex-5Q9XUB2Caenorhabditis elegansPredicted (SEA)2.95827
Carbonic anhydrase 7 structureClick to view 3D structureCarbonic anhydrase 7P43166HumansPredicted (SEA)59.399
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)104.24
Small ubiquitin-related modifier 1 structureClick to view 3D structureSmall ubiquitin-related modifier 1P63165HumansPredicted (SEA)4.35956
Click to view 3D structureType 1 fimbrin D-mannose specific adhesinP08191Escherichia coli K-12Predicted (SEA)1.79053
Carbonic anhydrase 9 structureClick to view 3D structureCarbonic anhydrase 9Q16790HumansPredicted (SEA)129.697
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)175.939
Carbonic anhydrase 4 structureClick to view 3D structureCarbonic anhydrase 4P22748HumansPredicted (SEA)60.8781
Click to view 3D structureLectinB4EH87Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Predicted (SEA)2.25763
Click to view 3D structureN-acetyllactosaminide alpha-1,3-galactosyltransferaseP50127Sus scrofaPredicted (SEA)2.25763
Click to view 3D structureAldo-keto reductase family 1 member B1P07943Rattus norvegicusPredicted (SEA)37.7569
Click to view 3D structureOligo-1,6-glucosidase IMA1P53051Saccharomyces cerevisiae S288cPredicted (SEA)5.2159
Click to view 3D structureAldehyde dehydrogenase, cytosolic 1P13601Rattus norvegicusPredicted (SEA)1.08989
Solute carrier family 28 member 3 structureClick to view 3D structureSolute carrier family 28 member 3Q9HAS3HumansPredicted (SEA)15.8034
Sodium/glucose cotransporter 1 structureClick to view 3D structureSodium/glucose cotransporter 1P13866HumansPredicted (SEA)11.1324
Lysine-specific histone demethylase 1A structureClick to view 3D structureLysine-specific histone demethylase 1AO60341HumansPredicted (SEA)130.397
Click to view 3D structureCarbonic anhydrase 5A, mitochondrialP35218HumansPredicted (SEA)200.695
Galectin-3 structureClick to view 3D structureGalectin-3P17931HumansPredicted (SEA)10.821
Click to view 3D structureBeta-1,4-galactosyltransferase 1P08037Bos taurusPredicted (SEA)3.97031
Aldo-keto reductase family 1 member B1 structureClick to view 3D structureAldo-keto reductase family 1 member B1P15121HumansPredicted (SEA)89.7602
Galectin-9 structureClick to view 3D structureGalectin-9O00182HumansPredicted (SEA)9.73115
Click to view 3D structureSolute carrier family 2, facilitated glucose transporter member 1P11167Rattus norvegicusPredicted (SEA)3.50322
Sodium/glucose cotransporter 2 structureClick to view 3D structureSodium/glucose cotransporter 2P31639HumansPredicted (SEA)12.923
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available