Sennosides (CED0006909)

Record Information

Version

1.0

Creation Date

2026-04-14 18:14:18 UTC

Update Date

2026-08-22 14:20:51 UTC

SynCED ID

CED0006909

Secondary Accession Numbers

CHEM131241

Identification

Common Name

Sennosides

Class

Small Molecule

Description

Sennosides belongs to the anthracenecarboxylic acids and derivatives, a subclass of anthracenes within the organic compounds. With an average molecular weight of 862.75 g/mol, Sennosides is a heavy molecule. It is characterized by the chemical formula C42H38O20 and is classified within the superclass of benzenoids. The compound is identified in seven recorded sources. These include household cleaning and consumer products such as pipe accessories and non electric simulated smoking devices, as well as electrical and electronic equipment including electrodes, television systems, and electrically stimulated smoking devices. Additionally, it is found in food preservation within the category of food, food processing and cookware, and is used in healthcare, pharmaceuticals and veterinary products as drugs for constipation. The recorded route of exposure for this compound is oral. At the molecular level, sennosides interact with two recorded protein targets. It acts as an inhibitor of Aquaporin-3 (AQP3) and Reverse transcriptase/RNaseH (pol).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₄₂H₃₈O₂₀

Average Molecular Mass

862.746 g/mol

Monoisotopic Mass

862.196 g/mol

CAS Registry Number

517-43-1

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

OCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O

InChI Identifier

InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)

InChI Key

IPQVTOJGNYVQEO-UHFFFAOYSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
LC-MS/MS	LC-MS/MS Spectrum	splash10-01p2-0014029240-8eed51bf761ee5079e67	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00dr-0094301000-9718c831fa5649005ec1	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0000000090-1bd0b04b288d1e20d03f	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0002001090-398271be6a426293523d	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0000001090-49ea15825f17aa180b7c	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0000000090-846387142135e14b55e2	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000j-0017019240-266a766689f646fbefc0	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0002001090-890251e147c278df1db1	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0000000090-da7e40a3ab3703a0b7c2	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00dr-0094400000-3b49f357e910e1f381e5	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0000000090-dae796a53c1c97327fe9	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0002000090-d7d363dbfaf0ba3dc104	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0001000090-69b3fd6f2c364bcc1097	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-0049218040-6a39c7ee08b0e2ffee74	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-01p2-0016119370-9a1e7760edc61797ab5d	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00dr-0094400000-d28c812b8c463c505e54	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000253	Drugs for constipation?Drugs for constipation, such as laxatives, are utilized to alleviate symptoms of constipation by promoting bowel movements.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	Not Available
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	Not Available
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	Not Available
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	Not Available
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	Not Available
CEDs000562	Pipe Accessories?Pipe accessories, such as fittings, connectors, and seals, are components used in plumbing systems to facilitate the flow of liquids and gases.	Household cleaning & consumer products	Not Available
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	Not Available
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	Not Available
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	Not Available
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	Not Available
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	Not Available
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	Not Available
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	Not Available
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	Not Available
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Hexokinase HKDC1	Q2TB90	Humans	Predicted (SEA)	Prediction Confidence Score 0.51 Applicability Domain 1.0 Statistical Significance 1.00e-04 Supporting Reference Compounds 69 E-value 0.778492
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	Prediction Confidence Score 0.371 Applicability Domain 0.386 Statistical Significance 0.0087 Supporting Reference Compounds 332 E-value 67.7288
Click to view 3D structure	Zinc finger protein mex-5	Q9XUB2	Caenorhabditis elegans	Predicted (SEA)	Prediction Confidence Score 0.366 Applicability Domain 1.0 Statistical Significance 3.80e-04 Supporting Reference Compounds 88 E-value 2.95827
Click to view 3D structure	Carbonic anhydrase 7	P43166	Humans	Predicted (SEA)	Prediction Confidence Score 0.356 Applicability Domain 0.386 Statistical Significance 0.0076 Supporting Reference Compounds 242 E-value 59.399
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.356 Applicability Domain 0.386 Statistical Significance 0.0134 Supporting Reference Compounds 407 E-value 104.24
Click to view 3D structure	Small ubiquitin-related modifier 1	P63165	Humans	Predicted (SEA)	Prediction Confidence Score 0.347 Applicability Domain 1.0 Statistical Significance 5.60e-04 Supporting Reference Compounds 95 E-value 4.35956
Click to view 3D structure	Type 1 fimbrin D-mannose specific adhesin	P08191	Escherichia coli K-12	Predicted (SEA)	Prediction Confidence Score 0.342 Applicability Domain 0.403 Statistical Significance 2.30e-04 Supporting Reference Compounds 4 E-value 1.79053
Click to view 3D structure	Carbonic anhydrase 9	Q16790	Humans	Predicted (SEA)	Prediction Confidence Score 0.337 Applicability Domain 0.386 Statistical Significance 0.0167 Supporting Reference Compounds 372 E-value 129.697
Click to view 3D structure	Carbonic anhydrase 2	P00918	Humans	Predicted (SEA)	Prediction Confidence Score 0.334 Applicability Domain 0.368 Statistical Significance 0.0226 Supporting Reference Compounds 472 E-value 175.939
Click to view 3D structure	Carbonic anhydrase 4	P22748	Humans	Predicted (SEA)	Prediction Confidence Score 0.334 Applicability Domain 0.368 Statistical Significance 0.0078 Supporting Reference Compounds 193 E-value 60.8781
Click to view 3D structure	Lectin	B4EH87	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))	Predicted (SEA)	Prediction Confidence Score 0.321 Applicability Domain 0.38 Statistical Significance 2.90e-04 Supporting Reference Compounds 3 E-value 2.25763
Click to view 3D structure	N-acetyllactosaminide alpha-1,3-galactosyltransferase	P50127	Sus scrofa	Predicted (SEA)	Prediction Confidence Score 0.301 Applicability Domain 0.301 Statistical Significance 2.90e-04 Supporting Reference Compounds 1 E-value 2.25763
Click to view 3D structure	Aldo-keto reductase family 1 member B1	P07943	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.3 Applicability Domain 0.368 Statistical Significance 0.0048 Supporting Reference Compounds 70 E-value 37.7569
Click to view 3D structure	Oligo-1,6-glucosidase IMA1	P53051	Saccharomyces cerevisiae S288c	Predicted (SEA)	Prediction Confidence Score 0.296 Applicability Domain 0.296 Low confidence Statistical Significance 6.70e-04 Supporting Reference Compounds 1 E-value 5.2159
Click to view 3D structure	Aldehyde dehydrogenase, cytosolic 1	P13601	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.292 Applicability Domain 0.329 Statistical Significance 1.40e-04 Supporting Reference Compounds 2 E-value 1.08989
Click to view 3D structure	Solute carrier family 28 member 3	Q9HAS3	Humans	Predicted (SEA)	Prediction Confidence Score 0.286 Applicability Domain 0.389 Statistical Significance 0.002 Supporting Reference Compounds 3 E-value 15.8034
Click to view 3D structure	Sodium/glucose cotransporter 1	P13866	Humans	Predicted (SEA)	Prediction Confidence Score 0.284 Applicability Domain 0.349 Statistical Significance 0.0014 Supporting Reference Compounds 14 E-value 11.1324
Click to view 3D structure	Lysine-specific histone demethylase 1A	O60341	Humans	Predicted (SEA)	Prediction Confidence Score 0.282 Applicability Domain 0.359 Statistical Significance 0.0167 Supporting Reference Compounds 85 E-value 130.397
Click to view 3D structure	Carbonic anhydrase 5A, mitochondrial	P35218	Humans	Predicted (SEA)	Prediction Confidence Score 0.282 Applicability Domain 0.362 Statistical Significance 0.0258 Supporting Reference Compounds 165 E-value 200.695
Click to view 3D structure	Galectin-3	P17931	Humans	Predicted (SEA)	Prediction Confidence Score 0.28 Applicability Domain 0.313 Statistical Significance 0.0014 Supporting Reference Compounds 23 E-value 10.821
Click to view 3D structure	Beta-1,4-galactosyltransferase 1	P08037	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.278 Applicability Domain 0.324 Statistical Significance 5.10e-04 Supporting Reference Compounds 2 E-value 3.97031
Click to view 3D structure	Aldo-keto reductase family 1 member B1	P15121	Humans	Predicted (SEA)	Prediction Confidence Score 0.278 Applicability Domain 0.359 Statistical Significance 0.0115 Supporting Reference Compounds 84 E-value 89.7602
Click to view 3D structure	Galectin-9	O00182	Humans	Predicted (SEA)	Prediction Confidence Score 0.277 Applicability Domain 0.313 Statistical Significance 0.0012 Supporting Reference Compounds 15 E-value 9.73115
Click to view 3D structure	Solute carrier family 2, facilitated glucose transporter member 1	P11167	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.275 Applicability Domain 0.349 Statistical Significance 4.50e-04 Supporting Reference Compounds 2 E-value 3.50322
Click to view 3D structure	Sodium/glucose cotransporter 2	P31639	Humans	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.349 Statistical Significance 0.0017 Supporting Reference Compounds 17 E-value 12.923