Solriamfetol (CED0011976)

Record Information
Version1.0
Creation Date2026-04-14 19:54:53 UTC
Update Date2026-08-18 00:58:42 UTC
SynCED IDCED0011976
Secondary Accession Numbers
  • CHEM132489
Identification
Common NameSolriamfetol
ClassSmall Molecule
Description
Solriamfetol is an organic compound with the formula C10H14N2O2 and an average molecular weight of 194.23 g/mol. Solriamfetol belongs to the phenethylamines, a subclass of benzene and substituted derivatives within the organic compounds. This compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically as psychostimulants, agents used for adhd and nootropics. The recorded exposure route for this substance is oral. Solriamfetol acts on two recorded protein targets, serving as an inhibitor of the sodium-dependent dopamine transporter (SLC6A3) and the sodium-dependent noradrenaline transporter (SLC6A2).
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC10H14N2O2
Average Molecular Mass194.234 g/mol
Monoisotopic Mass194.106 g/mol
CAS Registry Number178429-62-4
IUPAC NameNot Available
Traditional NameNot Available
SMILESN[C@@H](COC(N)=O)CC1=CC=CC=C1
InChI IdentifierInChI=1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1
InChI KeyUCTRAOBQFUDCSR-SECBINFHSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
1305.0 Log mg/kg [730:2300]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000378Psychostimulants, agents used for adhd and nootropics?Psychostimulants, including agents commonly prescribed for Attention Deficit Hyperactivity Disorder (ADHD) and nootropics, are synthetic chemicals that enhance cognitive function, attention, and alertness.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentPubChem
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsPubChem
Pathways
3 pathwaysPathway Source: PathBank
Solriamfetol Action Pathway
Solriamfetol Action Pathway
Solriamfetol Drug Metabolism Action Pathway
Solriamfetol Drug Metabolism Action Pathway
Solriamfetol Predicted Metabolism Pathway
Solriamfetol Predicted Metabolism Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Solute carrier family 15 member 1 structureClick to view 3D structureSolute carrier family 15 member 1P46059HumansPredicted (SEA)
Prediction Confidence Score
0.402
Applicability Domain
0.462
Statistical Significance
4.50e-04
Supporting Reference Compounds
3
E-value
3.50322
Click to view 3D structureMast cell carboxypeptidase AP15088HumansPredicted (SEA)
Prediction Confidence Score
0.395
Applicability Domain
0.405
Statistical Significance
2.10e-04
Supporting Reference Compounds
2
E-value
1.63483
Click to view 3D structureCytosol aminopeptidaseP28838HumansPredicted (SEA)
Prediction Confidence Score
0.394
Applicability Domain
0.444
Statistical Significance
6.00e-04
Supporting Reference Compounds
18
E-value
4.67095
Click to view 3D structurePeptidyl-glycine alpha-amidating monooxygenaseP19021HumansPredicted (SEA)
Prediction Confidence Score
0.386
Applicability Domain
0.386
Statistical Significance
4.20e-04
Supporting Reference Compounds
1
E-value
3.26967
Aminopeptidase N structureClick to view 3D structureAminopeptidase NP15144HumansPredicted (SEA)
Prediction Confidence Score
0.384
Applicability Domain
0.405
Statistical Significance
0.0025
Supporting Reference Compounds
42
E-value
19.3066
Serine racemase structureClick to view 3D structureSerine racemaseQ9GZT4HumansPredicted (SEA)
Prediction Confidence Score
0.381
Applicability Domain
0.381
Statistical Significance
2.50e-04
Supporting Reference Compounds
1
E-value
1.94623
Endoplasmic reticulum aminopeptidase 2 structureClick to view 3D structureEndoplasmic reticulum aminopeptidase 2Q6P179HumansPredicted (SEA)
Prediction Confidence Score
0.368
Applicability Domain
0.391
Statistical Significance
0.0024
Supporting Reference Compounds
22
E-value
18.9952
Click to view 3D structureCytosol aminopeptidaseP28839Sus scrofaPredicted (SEA)
Prediction Confidence Score
0.361
Applicability Domain
0.391
Statistical Significance
2.50e-04
Supporting Reference Compounds
11
E-value
1.94623
Aminopeptidase N structureClick to view 3D structureAminopeptidase NP15145Sus scrofaPredicted (SEA)
Prediction Confidence Score
0.361
Applicability Domain
0.391
Statistical Significance
0.0028
Supporting Reference Compounds
40
E-value
22.1092
Leukotriene A-4 hydrolase structureClick to view 3D structureLeukotriene A-4 hydrolaseP09960HumansPredicted (SEA)
Prediction Confidence Score
0.359
Applicability Domain
0.413
Statistical Significance
0.002
Supporting Reference Compounds
51
E-value
15.6477
Click to view 3D structureNeprilysinP07861Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.359
Applicability Domain
0.372
Statistical Significance
0.0027
Supporting Reference Compounds
38
E-value
20.7857
Neprilysin structureClick to view 3D structureNeprilysinP08473HumansPredicted (SEA)
Prediction Confidence Score
0.358
Applicability Domain
0.372
Statistical Significance
0.003
Supporting Reference Compounds
51
E-value
23.4326
Endoplasmic reticulum aminopeptidase 1 structureClick to view 3D structureEndoplasmic reticulum aminopeptidase 1Q9NZ08HumansPredicted (SEA)
Prediction Confidence Score
0.353
Applicability Domain
0.391
Statistical Significance
0.0027
Supporting Reference Compounds
19
E-value
20.9414
Neprilysin structureClick to view 3D structureNeprilysinP08049Oryctolagus cuniculusPredicted (SEA)
Prediction Confidence Score
0.352
Applicability Domain
0.372
Statistical Significance
0.0043
Supporting Reference Compounds
34
E-value
33.4752
Click to view 3D structureSodium-dependent dopamine transporterP23977Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.351
Applicability Domain
0.424
Statistical Significance
0.0074
Supporting Reference Compounds
203
E-value
57.5306
Cruzipain structureClick to view 3D structureCruzipainP25779Trypanosoma cruziPredicted (SEA)
Prediction Confidence Score
0.351
Applicability Domain
0.367
Statistical Significance
0.0043
Supporting Reference Compounds
65
E-value
33.4752
Carboxypeptidase A1 structureClick to view 3D structureCarboxypeptidase A1P00730Bos taurusPredicted (SEA)
Prediction Confidence Score
0.35
Applicability Domain
0.405
Statistical Significance
3.10e-04
Supporting Reference Compounds
9
E-value
2.41333
Click to view 3D structureAminopeptidase BO09175Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.347
Applicability Domain
0.378
Statistical Significance
5.80e-04
Supporting Reference Compounds
8
E-value
4.51525
Click to view 3D structureHistone deacetylase 6Q99P97Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.347
Applicability Domain
0.347
Statistical Significance
0.0022
Supporting Reference Compounds
1
E-value
17.2047
Cytosol aminopeptidase structureClick to view 3D structureCytosol aminopeptidaseP00727Bos taurusPredicted (SEA)
Prediction Confidence Score
0.347
Applicability Domain
0.347
Statistical Significance
0.0031
Supporting Reference Compounds
1
E-value
24.2111
Carboxypeptidase A1 structureClick to view 3D structureCarboxypeptidase A1P15085HumansPredicted (SEA)
Prediction Confidence Score
0.343
Applicability Domain
0.405
Statistical Significance
0.0013
Supporting Reference Compounds
13
E-value
10.5096
Procathepsin L structureClick to view 3D structureProcathepsin LP07711HumansPredicted (SEA)
Prediction Confidence Score
0.339
Applicability Domain
0.367
Statistical Significance
0.0146
Supporting Reference Compounds
167
E-value
113.348
Excitatory amino acid transporter 3 structureClick to view 3D structureExcitatory amino acid transporter 3P43005HumansPredicted (SEA)
Prediction Confidence Score
0.338
Applicability Domain
0.4
Statistical Significance
4.10e-04
Supporting Reference Compounds
13
E-value
3.19182
Angiotensin-converting enzyme structureClick to view 3D structureAngiotensin-converting enzymeP12821HumansPredicted (SEA)
Prediction Confidence Score
0.337
Applicability Domain
0.372
Statistical Significance
0.0082
Supporting Reference Compounds
46
E-value
63.525
Click to view 3D structureVoltage-dependent calcium channel subunit alpha-2/delta-1O08532Mus musculusPredicted (SEA)
Prediction Confidence Score
0.336
Applicability Domain
0.515
Statistical Significance
1.30e-04
Supporting Reference Compounds
3
E-value
1.01204
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available